Toxin-antitoxin Database (TADB) brings a detailed update on Toxin-Antitoxin classification in the different pathogens such as staphylococcus aureus, streptococcus pneumonia, Vibrio cholerae, Salmonella typhimurium, Shigella flexneri, and helicobacter pylori, etc. So, this Toxin-Antitoxin system is a ...
Although toxin–antitoxin gene cassettes were first found in plasmids, recent database mining has shown that these loci are abundant in free-living prokaryotes, including many pathogenic bacteria. For example, Mycobacterium tuberculosis has 38 chromosomal toxin–antitoxin loci, including 3 relBE and 9...
Akarsu H, Bordes P, Mansour M, Bigot DJ, Genevaux P, Falquet L (2019) TASmania: a bacterial toxin-antitoxin systems database. PLoS Comput Biol 15:e1006946. https://doi.org/10.1371/journal.pcbi.1006946 Article CAS PubMed PubMed Central Google Scholar Andrews ES, Arcus VL (2015) The...
Prokaryotic toxin–antitoxin stress response lociBacteriaMycobacterium tuberculosisChromosomes, BacterialBacterial ToxinsAntitoxinsChromosome MappingPlasmidsApoptosisOperonRNA, MessengerAlthough toxin–antitoxin gene cassettes were first found in plasmids, recent database mining has shown that these loci are abundant ...
As of June 2015, TADB, the web-based toxin-antitoxin database managed by our group, has collected 6,156 putative TA loci in 679 bacterial and archaeal genomes8; interestingly, 214 of the collected TA loci had been assigned to the relBE family. relBE is one of the best-documented type ...
tuberculosis. The genes associated with the toxin-antitoxin system were obtained from the National Center for Biotechnology Information (NCBI) Gene database. Mutations correlating with enhanced transmission within the genes were identified by using random forest, gradient boosting decisi...
classification is still problematic, functional assignment is suggested through domain identification. The power of RASTA-Bacteria in annotating putative TA modules stems from it combining detection of function, using a new knowledge-based database (TAcddb), and genomic context of the genes (small ...
TADB (http://bioinfo-mml.sjtu.edu.cn/TADB/) is an integrated database that provides comprehensive information about Type 2 toxin鈥揳ntitoxin (TA) loci, gen... Y Shao,EM Harrison,D Bi,... - 《Nucleic Acids Research》 被引量: 346发表: 0年 A Novel Family of Escherichia coli Toxin-A...
Data availability The bioinformatic analysis was performed using protein sequences available in the Integrated Microbial Genomes (IMG) database (https://img.jgi.doe.gov/). DarTG1 and DarTG2 were identified in Escherichia coli C7 (NCBI accession GCA_001901425.1) and Escherichia coli 2-460-02_S4...
suis SC84 were predicted with TAfinder, a newly developed online tool in TADB (Toxin-Antitoxin Database, http://202.120.12.135/TADB2/Introduction.html#table_s2), which can quickly detect the TA prediction [12]. Nine putative type II TA systems are shown in Table 1 and distributed widely ...