Since toxins in your body can affect nutrient absorption, detoxification can become even more important than nutrition. This is where toxin binders come in. Binders can bind to toxins inside your body and help to remove them. In this article, you will learn about toxins in our environment. Yo...
Mini-protein binders that exhibit binding affinity ranging from the picomolar to the nanomolar range for a wide range of target proteins have been designed from scratch41,46. Nevertheless, designing binders that can broadly and effectively bind different protein target subtypes presents a substantial ...
For the treatment of Clostridium difficile infection, the tetraspecific octameric binding agent and antibody against Clostridium difficile toxin A and toxin B Novel antibody based binders derived from human immunoglobulins and camelid immunoglobulins have been described. These binders recognize and specifically...
Mini-protein binders are small globular proteins consisting of 37–65 amino acids40,41,42,43,44,45. They have been specifically designed with surface residues that allow for the formation of shape- and chemical-complementary interactions with the structural epitope on the target molecule. The mini...
Like antibodies, aptamers have a defined three dimensional structure that allows for specific interaction with the target. Additionally, they are faster and easier to select from a library of binders compared to immunoreagents, and once the sequence of aptamer is known, it can be easily chemically...
To identify ligand binders, anticalin libraries are created with targeted random mutagenesis of 16–24 amino acids at exposed positions, which is primarily the tips of the four loops [159]. Subsequently, phage display selection and microculture screening in combination with ELISA is used for ...