Type I toxin-antitoxin systems in Bacillus subtilis. RNA Biol 2012; 9:1491-7; PMID:23059907; http:// dx.doi.org/10.4161/rna.22358Durand, S., Jahn, N., Condon, C. & Brantl, S. (2012a). Type I toxin-antitoxin systems in Bacillus subtilis. RNA Biol 9, 1491-1497....
Of the currently known six types of TA systems, in Bacillus subtilis, so far only type I and type II TA systems were found, all encoded on the chromosome. Here, we review our present knowledge of these systems, the mechanisms of antitoxin and toxin action, and the regulation of their ...
In subject area: Medicine and Dentistry TA systems are genetic modules in bacteria that encode both a stable toxic protein and a labile antitoxin which neutralizes the toxin’s activity. From: Trends in Microbiology, 2020 About this pageAdd to MendeleySet alert ...
Type I toxin-antitoxin systems inBacillus subtilis Type I toxin-antitoxin (TA) systems are widespread in bacteria and consist of a toxin-encoding mRNA and a partially overlapping antisense RNA that blocks e... Sylvain,Durand,Natalie,... - 《Rna Biology》 被引量: 58发表: 2014年 One antitoxin...
To avoid ambiguity arising from the presence of multiple TA modules in E. coli, the effect of the sole type-2 toxinantitoxin module of Bacillus subtilis was examined for several types of lethal stress. Methodology/Principal Findings: Genetic knockout of the toxin gene, ndoA (ydcE), conferred...
Toxin–antitoxin systems are widespread in bacterial genomes. They are usually composed of two elements: a toxin that inhibits an essential cellular process and an antitoxin that counteracts its cognate toxin. In the past decade, a number of new toxin–antitoxin systems have been described, bringing...
The PTM activity of FIC was originally discovered in effector proteins delivered by the T3SS or T4SS secretion systems of some pathogenic bacteria to manipulate host cell processes23,24,25. Later, PTM activity was also identified in the toxin component of bacterial toxin–antitoxin modules (e.g....
Toxin-antitoxin (TA) systems are broadly distributed, yet poorly conserved, genetic elements whose biological functions are unclear and controversial. Some TA systems may provide bacteria with immunity to infection by their ubiquitous viral predators, bacteriophages. To identify such TA systems, we searc...
chromosomal relBE toxin- antitoxin locus in Streptomyces cattleya DSM46488 Peng Li1, Cui Tai1, Zixin Deng1, Jianhua Gan2, Marco R. Oggioni3 & Hong-Yu Ou1 The relBE family of Type II toxin-antitoxin (TA) systems have been widely reported in bacteria but none in ...
One such mechanism involves type VI secretion systems, which bacteria can use to inject antibacterial toxins directly into neighbouring cells. Many of these toxins target the integrity of the cell envelope, but the full range of growth inhibitory mechanisms remains unknown2. Here we identify a type...