In our opinion, the utility of the acute LC50 assay is more limited than is currently understood or taught in training programs, and the conduct of this test should be minimized as much as feasible, not only because of humane considerations but also for reasons that are both scientific and ...
Just as there were initially several different preclinical toxicology programs and study designs in the different regulatory regions prior to harmonization, there were likewise different requirements for how the data and the reports were to be presented to regulatory agencies in Europe, Japan, and th...
Due to the noninvasive speci- men's collection, cumulative register of substances, wider detection window and easy storage, sweat testing has been applied in the context of criminal justice system, to verify drug intake by subjects in parole/probation programs. Sweat can also be tested for drug...
This knowledge has already found its way into the contents of academic teaching programs in medical schools and postgraduate courses (e.g. in molecular epidemiology, neurosciences, personalized medicine). In contrast, the other major and modifiable dimension of pathogenesis, the influence of ...
(Egeghy et al.2016). In biomonitoring programs, usually the parent compounds or their metabolites are measured in urine (LaKind et al.2019). Such measurements are per nature highly variable due to the fast elimination of non-persistent chemicals from the body. The US-EPA (Breen et al.2021...
Since a covalent modification such as thiolation or nitration changes a peptide mass by a known amount, it is possible through MASCOT and other programs to identify both a protein and its posttranslational modifications. Statistical Analysis All data were plotted as mean ± SEM and analyzed using ...
[197]. Some companies (a minority) were using inappropriate occupational environmental clean-up methods, such as sweeping and compressed air [198]. These results suggest more widespread adoption of nano-specific environmental health and safety programs and the use of PPE in the absence of superior...
nuclear DNA methylation distribution patterns have proven to serve as an indicator of topological changes of the genome that could perturb spatial interactions of genomic loci and subsequent expression programs leading to cytotoxicity in treated cells. This is quite conceivable as it has been observed ...
Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide range of pharmacological properties, which can be exploited in drug discovery programs. In this work we review the current body of knowledge regarding the chemistry, toxicology, ...
Preventing Suicide: A Technical Package of Policies, Programs, and Practices. National Center for Injury Prevention and Control, Centers for Disease Control and Prevention; 2017. 38. Centers for Disease Control and Prevention. Evidence-Based Strategies for Preventing Opioid Overdose: What's Working ...