monocytogenes shuts down the transcription of genes involved in heme/iron uptake and utilization. Furthermore, heme stress resulted in a massive increase in the transcription of a putative heme detoxification system, hrtAB, which is highly conserved in Gram-positive bacteria. As expected, we found ...
We’re supposed to avoid plastics #3 (PVC), #6 (polystyrene), and #7 (polycarbonate). Polycarbonate is the plastic that is made from the chemical Bisphenol-A (BPA). AndBPA has a bad rapbecause it’s a hormone-disruptor. Walk down the aisles of any drug store these days, and you’...
RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome. Hum. Mol. Genet. 24, 4317–4326 (2015). Article CAS PubMed PubMed Central Google Scholar Green, K. M. et al. RAN translation at C9orf72-associated repeat...
Global microplastic contamination of almost all biological and environmental media is an emerging threat to human health that recently fostered intense res
There is also a significant knowledge gap regarding the effects of major or active components of essential oils on the insect nervous system32,33. The possible target sites for the essential oil components thymol, eugenol, and carvacrol are gamma-amino butyric acid (GABA), octopamine/tyramine and...
Once the dosing of six mice at 1000 mg/kg was completed without any deaths, it was concluded that the LD50 of GK-1 by subcutaneous route in female BALB/c mice was over 1000 mg/kg, which would classify GK-1, at least, as Globally Harmonized System of Classification and Labelling ...
In this study, we characterized the Drosophila model of AβpE3-42 toxicity by expressing the peptide in specific sets of neurons using the GAL4-UAS system, and measuring different phenotypic outcomes. We found that AβpE3-42 peptide had an increased propensity to aggregate. Expression of Aβ...
The blood-brain barrier (BBB) is a unique system of blood vessels that vascularize the central nervous system (CNS), allowing the exchange of substances between the blood and the neural tissue and protecting the CNS from toxins, pathogens and exogenous particles [55]. However, previous studies...
wherein at least one or more of the amino acids selected from the group consisting of Q27(VL); D28(VL), N30(VL), T31(VL), A32(VL), Y49(VL), F53(VL), Y55(VL), R66(VL), H91(VL), Y92((VL), and T94(VL), numbered according to the Kabat numbering system, are substitu...
wherein at least one or more of the amino acids selected from the group consisting of Q27(VL); D28(VL), N30(VL), T31(VL), A32(VL), Y49(VL), F53(VL), Y55(VL), R66(VL), H91(VL), Y92((VL), and T94(VL), numbered according to the Kabat numbering system, are substitu...