Solid lipid nanoparticles reduce systemic toxicity of docetaxel: Performance and mechanism in animal. Nanotoxicology 2011 Feb 9.Gao Y,Yang R,Zhang Z. Solid lipid nanoparticles reduce systemic toxicity of docetaxel:performance and mechanism in animal[J].Nanotoxicology,2011,(04):636-649....
mRNA formulated with lipid nanoparticles is a transformative technology that has enabled the rapid development and administration of billions of coronavirus disease 2019 (COVID-19) vaccine doses worldwide. However, avoiding unacceptable toxicity with mRNA drugs and vaccines presents challenges. Lipid nanop...
Inhaled nanoparticles trapped in the mucus of the respiratory tract can also be swallowed and trans-located into the GI tract. In the human GI tract, the production of acid and enzymes by the gastric mucosa can influence properties of ingested nanomaterials. The gastric phase for food digestion ...
However, to minimize the influence of methanol on the experimental system, its final concentration in all exposure solutions was reduced to less than 0.1% (v/v), a level considered negligible and unlikely to impact interactions between nanoparticles (NMPs) and FPP or to affect bioavailability and...
Nano- particles have received much attention due to their toxicity imposed on the environment during production and disposal of consumer products [12] (Fig. 1). They impose toxicity by various processes. Nanoparticles can easily cross the cell 1 3Vol.:(0123456789) 2 44 Fig. 1 ...
The hydrogen peroxide level and lipid peroxidation levels increased significantly in roots after exposure to 20 and 50mg/L of silver nanoparticles. Histochemical staining with nitroblue tetrazolium showed a concentration-dependant increase in superoxide formation in roots. Roots treated with 2′, 7′-...
The toxicity of metal oxide nanoparticles, such as nano-TiO2, nano-ZnO, nano-CuO, nano-CuZn, nano-Fe3O4, and nano-Fe2O3, with nano-TiO2, nano-ZnO in particular, has been reported [6], [12], [29], [30], [31]. As expected, different nanomaterials exhibit different toxic potency...
(~1 μm) enter cells mainly through phagocytosis, and smaller PCGO nanoparticles (~500 nm) enter cells primarily through clathrin-mediated endocytosis [88]. GO sheets could adhere and wrap around the cell membrane, insert in the lipid bilayer or be internalized into the cell as a consequence...
Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for pulmonary application: A review of the state of the art 2014, European Journal of Pharmaceutics and Biopharmaceutics Show abstract Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms 2016, Arch...
Silica nanoparticles exert detrimental effects on the respiratory system, regardless of the exposure route. The adverse outcome pathway framework has been recently developed in toxicological research to characterize the pathways that lead to harmful outcomes. Here, we review the adverse effects of amorphou...