There are two main reasons for this: (1) some members of a class of substances are so potent that their inclusion in the database would skew the TTC to such an extent that use of the TTC would be of no practical value; (2) no or very few substances in a class were included in ...
A PCB toxicity problem affects children more than adults. A lowered immune system can lead to complications in children, such as sensitivities, allergies, and chronic infections. Still, a heavy concentration of PCB toxins in adults over time may cause impairments in the brain, nervous system, imm...
genetically at risk for alcoholism, are more sensitive to the early pleasurable effects of alcohol that occur as the blood alcohol level begins to rise but acquire acute functional tolerance so that they are less sensitive to the intoxicating and sedative effects—meaning that they can keep drinkin...
Marcasiteis a polymorph of pyrite, meaning they share the same chemical formula (FeS₂) but have different crystal structures. Pyrite crystallizes in the isometric system (cubic or octahedral shapes), while marcasite crystallizes in the orthorhombic system (often with a prismatic or radiating habit)...
One thing Eric wanted us to focus on — and why the album sounds different than the other records — was to play through. Meaning: we weren't cutting and pasting perfect choruses. He was more focused on playing the song from the beginning to middle to end...
Cytomegalovirus (CMV) is a globally endemic latent herpes virus that profoundly impacts T cell immunity. We investigated the oncological consequences of CMV infection across 341 prospectively recruited patients receiving immune checkpoint blockade (ICB)
Current system69,70,71, the dissolved fraction of baleen fecal samples was between 103to over 105times higher than average [dFe] in the open ocean. Fig. 1: Dissolved iron, copper, and metal-binding ligand concentrations. ADissolved iron concentrations ([dFe]) of our sample set compared with...
The discovery of new molecular targets of crystalline as well as amorphous silica particles in the immune system and in epithelial lung cells represents new possible toxicity pathways. Cellular recognition systems that detect specific features of the surface of silica particles have been identified. ...
However, it must be recognized that the use of the phrase “environmentally related” should be construed in its broadest meaning, that is, everything that is not genetic. Thus, environmental causes by this definition include such things as diet, smoking and drinking habits, and other lifestyle...
One of the important principles of toxicology is that there are specific mechanisms of action by which chemicals interact with the biological system to produce adverse effects. A considerable amount of research has gone into identifying the targets and initiating mechanisms for developmental toxicants (...