Functional cureDirect-acting antiviralsGene silencingImmunotherapyTherapeutic vaccinationHepatitis B virus(HBV)infection,although preventable by vaccination,remains a global health problem and a major cause of chronic liver disease.Although current treatment strategies suppress viral replication very efficiently,...
A functional cure in the host may require several synergistic antiviral and immunological intercessions. The correct sequencing and combinations of treatment with either host or viral targeting agents have yet to be determined. Proven surrogates for cccDNA for clinical trials are required. Different ...
The most important functional elements in CRISPR systems are Cas proteins encoded upstream of the CRISPR array and control system operation [20,21]. Class 1 and Class 2 are the two main classes in which the CRISPR-Cas system is categorized. There are six types (I to VI), and multiple ...