neuropathytotal neuropathy scoreThe aim of this multi-center study was to assess with reduced versions of the Total Neuropathy Score (TNS), the severity of chemotherapy-induced peripheral neurotoxicity (CIPN),
Composite scales such as the Total Neuropathy Score clinical version (TNSc©) have been widely used to measure neurological impairment in a standardized manner but they have been criticized due to their ordinal setting having no fixed unit. This study aims to improve impairment assessment in patie...
Nonetheless, use of systemic chemotherapy in clinical stage II disease may expose patients to unnecessary treatment-related toxic effects including oxaliplatin-related neuropathy and even hospitalization. Use of systemic chemotherapy for LARC is in keeping with the consensus approach per the NCCN guidelines...
The most common severe toxic effects were diarrhea (5 patients), neutropenia (2 patients), and peripheral neuropathy (2 patients). All grade 3 and 4 toxicities were reported during FOLFIRINOX induction, with only grade 1 and 2 toxicities reported during chemoradiotherapy. There were no deaths ...
Key findings:The combined treatment of CBD-enriched cannabis oil and ω-3 effectively prevented thermal and mechanical hypersensitivity, while also improving motor impairment-induced peripheral neuropathy. Finally, combination treatment showed a protective effect against degeneration resulting from CCI. ...
described a significant decrease in serum levels of pro-inflammatory cytokines, including IL-6 and TNF-α, following EPO treatment in patients with diabetic neuropathy [26]. Similarly, Tanaka et al. revealed that using erythropoietin-stimulating agents was significantly correlated with reduced levels ...
described a significant decrease in serum levels of pro-inflammatory cytokines, including IL-6 and TNF-α, following EPO treatment in patients with diabetic neuropathy [26]. Similarly, Tanaka et al. revealed that using erythropoie- tin-stimulating agents was significantly correlated with reduced...
In contrast, Dora (16 cases) [5] reported a high complications rate: one superficial superinfection, one trochanteric non-union, one anterior dislocation, five trochanteric bursites on cerclage wires, and one unexplained neuropathy; seven redo opera procedures were necessary. Risk is clearly greater...
Oxidative stress plays an substantial role in the pathogenesis of diabetes and its complications, including diabetic neuropathy, nephropathy, retinopathy, and macrovascular complications, among a multitude of related problems [1,2]. At the most basic level, oxidative stress caused by redox imbalance imp...
MK-801 blocks the development of thermal hyperalge- sia in a rat model of experimental painful neuropathy. Brain Res 1991; 553: 327-30. 8 Seltzer Z, Cohn S, Ginzburg R, Beilin B. Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury ...