Editor In their recent review on total neoadjuvant therapy (TNT) for rectal cancer, Zaborowski et al.1 conclude that TNT should be considered in patients with high‐risk, locally advanced rectal cancer. However, is there enough evidence for this recommendation? Almost one‐third of the patients ...
Yet for PDAC, the concept of TNT is itself nebulous in its meaning, although it is used to promote a strategy of maximum nonsurgical therapy before surgery. Thus far, there is no evidence to show how this TNT approach compares to partial (or something less than total) neoadjuvant ther...
(一)全程新辅助治疗(total neoadjuvant therapy,TNT) TNT已成为局部进展期直肠癌治疗的重要方案,被国内外指南所推荐。2023年版《国家卫生健康委员会中国结直肠癌诊疗规范》指出,对于具有高危复发因素的Ⅱ~Ⅲ期直肠癌,或者为保留肛门括约肌需增加肿瘤退缩或争取观察等待策略(watch and wait,W&W)者,推荐放化疗或短程放疗...
Thus, all patients treated before this date received the non-TNT approach, and those treated after this date received TNT. From 01/01/2022 (Fig. 1): Fig. 1 (a) Without re-evaluation. TNT: Total Neoadjuvant Therapy, TME: Total Mesorectal Excision, mrf: Mesorectal fascia; EMVI: ...
doi:10.1001/jamanetworkopen.2020.30097 editorial comment icon Editorial Comment Invited Commentary Personalizing Treatment for Rectal Cancer Noam VanderWalde, MD, MS; Axel Grothey, MD JAMA Network Open Key Points Question Is total neoadjuvant therapy (TNT) associated with improved outcomes when compared ...
The rationale for the RETRY trial is based on the hypothesis that total neoadjuvant therapy (TNT) with re-irradiation, based on the most advanced RT techniques, followed by consolidation CHT, is an effective method to improve outcomes in LRRC patients previously irradiated to the pelvis. The obj...
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Thomas J. George, MD, FACP, highlights the long-term data from the NRG-GI002 trial, the next steps for exploring subsets of patients who may benefit from the addition of pembrolizumab or veliparib to total neoadjuvant therapy, and what the use of total n
The main concern in the TNT concept is the delay of radical surgery. This could potentially lead to an expansion of the primary tumor, its invasion to local structures, or metastatic spread, in case of tumor resistance to the neoadjuvant therapy. The studies showed no differences in the propor...
Induction or consolidation chemotherapy with chemoRT prior to surgery for LARC, referred to as total neoadjuvant therapy (TNT), has been reported by several centers2-4 with the following benefits: improved delivery of planned therapy, increased downstaging, earlier introduction of optimal systemic ...