This analysis revealed four constituent fragments—the C1-C5 fragment 93, the The Journal of Antibiotics Challenges of complex polyketide natural products I Paterson and NYS Lam 227 Scheme 16 Fragment union and completion of the total synthesis of rhizopodin (3). C6-C13 fragment 94, the C14-C...
Among the vast chemical space carved out by nature are the polyketides, typified by their dazzling array of functionality and stereochemistry, providing a testing intellectual challenge for the synthetic chemist. Enticed by these intriguing structures, which generally have impressive biological activities,6...