BRCA1 is critical for DNA double-strand break (DSB) repair by homologous recombination (HR). BRCA1 deficient mice are embryonic lethal. Previous studies have shown that 53BP1 knockout (KO) rescues embryonic lethality of BRCA1 hypomorphic mutant mice by r
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6 Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA; sohail3553@gmail.com (S.A.S.); Aldo_t86@hotmail.com (A.T.-O.) 7 Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine, Siriraj Hospital, ...