Deletion of SIR2 or expression of a phospho-mutant form of SIR2 increased PMA1 expression, pHc, and vacuolar pH in the tor1 Delta mutant, suggesting a functional interaction between Sir2 and TORC1 signaling. Furthermore, deletion of TOR1 or KNS1 encoding a LAMMER kinase decreased the ...
Loewith R (2010) TORC1 signaling in budding yeast. In: Hall M, Tamanoi F, editors. The enzymes: structure, function and regulation of TOR complexes from yeasts to mammals. Burlington: Academic Press. pp. 147–175.Loewith, R. (2010) TORC1 signaling in budding yeast. Enzymes 27, 147-...
OPEN REVIEW ARTICLE Citation: Cell Discovery (2016) 2, 15049; doi:10.1038/celldisc.2015.49 www.nature.com/celldisc Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling Katie Powis, Claudio De Virgilio Department of Biology, University of Fribourg, Fribourg, ...
TORC1 and PKA signaling.aWorking model of the TORC1–PKA signaling circuit. The TORC1 and PKA kinases regulate the transcriptional activator, Sfp1, and the transcriptional repressors, Stb3 and Dot6/Tod6, to control expression of the protein and ribosome synthesis genes, as described in the t...
Here we report that TORC1 signaling upon heat stress is regulated by stress granules (SGs), which are cytoplasmic foci formed under certain stresses. Ectopic formation of SGs achieved by Pbp1 overexpression in unstressed cells sequesters TORC1 in this compartment, thereby blunting TORC1 signaling. ...
The TORC1 signaling pathway controls cellular growth through activation of anabolic processes such as protein, lipid, and nucleotide synthesis and repression of catabolic processes such as autophagy and proteasomal activity. Dysregulation of TORC1 signaling has been implicated in a diverse set of common...
Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. ...
The highly conserved target of rapamycin complex 1 (TORC1) is the central component of a signaling network that couples a vast range of internal and external stimuli to cell growth, proliferation and metabolism. TORC1 deregulation is associated with a number of human pathologies, including many ca...
The target of rapamycin complex 1 (TORC1) integrates various hormonal and nutrient signals to regulate cell growth, proliferation, and differentiation. Amino acid-dependent activation of TORC1 is mediated via the yeast EGO complex (EGOC) consisting of Gt
Keywords: Crystal structure; EGO complex; Rag GTPase; TORC1 signaling; growth control Cell Research (2015) 25:1043-1059. doi:10.1038/cr.2015.86; published online 24 July 2015 Introduction The target of rapamycin complex 1 (TORC1) is a highly conserved protein kinase complex that couples a ...