Topical delivery of methotrexate (MTX) has become an option to overcome the side effects caused by systemic therapy in psoriasis, leading to the suppression of NF-魏B activation through boosting adenosine release. However, thickened psoriatic skin is the primary restriction against local drug delivery...
PDE4 is an intracellular enzyme mainly present in immune, epithelial, and brain cells that regulates inflammation and epithelial integrity by degrading cyclic adenosine monophosphate [28]. PDE4 inhibition mediates inflam- matory cytokines and has been utilized in various forms for respiratory diseases,...
The first drug to be licensed,crisaborole, is a phosphodiesterase (PDE) 4 antagonist. In AD, elevatedPDEactivity was found compared with normal skin.21,22PDE hydrolyzes cyclic adenosine monophosphate (cAMP) and results in up-regulation ofinflammatory mediators. PDE antagonism acts in a broad, no...
either in the central nervous system by inhibiting neuronal reuptake of norepinephrine and serotonin or in the periphery by the blockade of Na+, K+, Ca2+ voltage-gated ion channels 15–17 and muscarinic, cholinergic, nicotinic, histaminergic, α2-adrenergic, adenosine and NMDA receptors [87,88,...
antibodies gen- erated against the ligand-binding domain of the receptor or small-molecule tyrosine kinase inhibitors (TKIs) that compete with the intracellular adenosine triphosphate binding domain of the receptor.2 Dermatologic toxic effects are the major side effects associated with EGFR inhibition. ...
antibodies gen- erated against the ligand-binding domain of the receptor or small-molecule tyrosine kinase inhibitors (TKIs) that compete with the intracellular adenosine triphosphate binding domain of the receptor.2 Dermatologic toxic effects are the major side effects associated with EGFR inhibition. ...
Imiquimod belongs to the family of synthetic small nucleotid-like molecules of imidazo-quinolinamines. It is an immune response modifier (IRM) with potent antiviral and antitumoral effects that are mediated through Toll-like receptor (TLR)7 (and 8) signaling. Imiquimod targets predominantly TLR7 ex...
ATP has two high-energy phosphate bonds per molecule, thereby yielding a free energy of about 7.3 kcal/mol when hydrolyzed around a neutral pH and itself being converted into adenosine diphosphate. Thus, the energy yielded from ATP hydrolysis allows nucleic acid synthesis as well as various metabo...
20090269303 METHOD FOR TREATING OR PREVENTING CONDITIONS BY ELEVATION OF THE ADENOSINE LEVEL IN AN INDIVIDUAL October, 2009 Jalkanen 20120225020 UNSATURATED CHOLINE ANALOGS AND CHEMICAL SYNTHESIS THEREOF September, 2012 Chekmenev et al. 20120014917 METHODS OF TREATING HIV PATIENTS WITH ANTI-FIBROTICS Januar...
tyrosine and/or its derivative, protein hydrolysate, adenosine-triphosphate and a substance comprising riboflavin and lyxoflavin EP0221728 1987-05-13 Monosaccharide containing wound healing preparation EP2774481 September, 2014 Antimicrobial compositions WO2009007307A1 2009-01-15 SELF-TANNING COMPOSITIONS WITH...