Two years later, and the gamble proved to be disastrous. Signs of problems with the drug were first evident in January 2021 when it failed to outperform Keytruda in theINTR@PID Lung 037trial, which enrolled patients with stage 4 non-small cell lung cancer with high expression of the PD-L1...
But the Swiss pharma giant is moving past cancer drugs and focusing on other therapeutic areas, including asthma and pulmonology. In August 2014, the company laid down $8.3 billion for InterMune ($ITMN) to add the drugmaker's idiopathic pulmonary fibrosis drug Esbriet (pirfenidone) to its resp...
a randomized, double-blind and placebo-controlled trial, a total of 106 hospitalized patients with a diagnosis of coronavirus SARS-CoV-2 infection (confirmed by polymerase chain reaction test) and signs of an acute respiratory infection but not requiring mechanical...
Monitoring Considerations:Consider monitoring for CBC changes, signs and symptoms of prolactin excess, and pulmonary hypertension. Most Common Adverse Reactions for BELVIQ In patients without diabetes: headache (17%), dizziness (9...
signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy...
account of signs of developing liver toxicity in patients, the drug showed some promise when paired with a white cell booster from Sanofi ($SNY). That tandem kept more than two-thirds of melanoma patients alive after a year of treatment, compared with just half of those who took only ...
Quintiles signs an expansive deal to chart effects of physical therapy Quintiles keeps rolling with another $1B quarter Quintiles targets healthcare providers with its latest buy -- Damian Garde (email |Twitter) Robin Washington, Gilead Sciences ...
chronic obstructive pulmonary disease (COPD)cystic fibrosis (CF)Cystic fibrosis (CF) is a life-shortening genetic disease affecting approximately 70 000 individuals worldwide. Until recently, drug development efforts have emphasised therapies treating downstream signs and symptoms resulting from the ...
signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy...
signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy...