they would be targeted by the mitochondrial protein-import machinery and become stuck in a TIM–TOM complex at the first prohibitively hydrophobic domain. This would inactivate the TIM–TOM complex unless and until the protein is degraded from either side, a process that has not yet been identifi...
This TOM-TIM23 supercomplex provides a fascinating import intermediate which can be stabilized if the precursor contains a tightly folded moiety at the C-terminus that is not able to pass through the TOM complex. Such a supercomplex can be generated during in vitro import, and in vivo. The ...
据悉,该研究团队于2020年9月8日在Cell Research杂志上首次报道了线粒体内膜TIM22转位酶复合体的组成全貌,于2021年4月13日在Cell Discovery杂志上报道了线粒体外膜TOM转位酶复合体的二聚体与三聚体转换调控机制。此次Science报道的TOM转位...
据悉,该研究团队于2020年9月8日在 Cell Research 杂志上首次报道了线粒体内膜TIM22转位酶复合体的组成全貌,于2021年4月13日在 Cell Discovery 杂志上报道了线粒体外膜TOM转位酶复合体的二聚体与三聚体转换调控机制。此次 Science 报道的TOM转位酶复合体组装机制,是该研究团队聚焦线粒体蛋白转运分选分子机制的又一...
The translocase of the outer mitochondrial membrane (TOM complex) facilitates the import of proteins through the outer mitochondrial membrane, while the complementary translocase of the inner membrane (TIM complex) is responsible for protein transport to the mitochondrial matrix. The TOM complex consists...
The TOM and TIM23 complexes facilitate the transport of precursor proteins with N-terminal targeting signals into the matrix. During transport, precursors are recognized by the TIM23 complex in the inner membrane for handover from the TOM complex. However, we have little knowledge on the ...
(1999) Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex. EMBO J., 18, 3214- 3221.M. Endres, W. Neupert and M. Brunner, Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex, EMBO J 18 (1999) ...
据悉,该研究团队于2020年9月8日在 Cell Research 杂志上首次报道了线粒体内膜TIM22转位酶复合体的组成全貌,于2021年4月13日在 Cell Discovery 杂志上报道了线粒体外膜TOM转位酶复合体的二聚体与三聚体转换调控机制。此次 Science 报道的TOM转位酶复合体组装机制,是该研究团队聚焦线粒体蛋白转运分选分子机制的又一...
This causes pb2-DHFR to link only a part of the TOM complex pool to the protein import machinery of the inner membrane (the TIM complex) as the TOM complex is present in large excess over the TIM complex [31], [39]. Therefore under the resting state conditions applied in the presence...
Under the normal condition of cells, Pink1 travels through the TOM and TIM protein complex from the outer to the inner mitochondrial membrane, but, its hydrophobic region is rich in proline and glycine amino acids which clog their movement to the membrane spanning region of the inner ...