The Tom complex has been reported to be important for Bax mitochondrial localization to induce cytochrome c release.38 We thus investigated whether Bax is involved in iron-induced pyroptosis via Tom20 modulation. The CCCP/iron treatment clearly induced Bax translocation from cytoplasm to mitochondria ...
Results: We found that after the establishment of their PPI, Hsp70 and Bim form a complex with parkin and TOMM20, which in turn facilitates parkin translocation to mitochondria, TOMM20 ubiquitination and mitophagic flux independent of Bax/Bak. Moreover, S1g-2 selectively inhibits stress-induced ...
, 2015). AIP also interacts with survivin, an inhibitor of apoptosis, and forms a complex with it in addition to Hsp90. The result is the prevention of ubiquitinations, thus stabilizing it. This interaction can be altered by another partner, RET, which will prevent the formation of the ...
Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem. 2003;278:8516–25. Article CAS PubMed Google Scholar Flones IH, Fernandez-Vizarra E, Lykouri M, Brakedal B, Skeie GO, Miletic H, et al. Neuronal ...
Accordingly, for the handover of the precursor from TOM to the TIM23 complex, both complexes need to be in proximity to each other. A complex set of protein interactions among IMS-domains of Tom22, Tim50, Tim23, and Tim21 and with the presequence of the incoming precursor are thought ...
Alternatively, the large complexes of p27 could be intermediates in the assembly of the RCNMV replicase complex, and Hsp70 might assist the assembly of these complexes into functional replicase complexes. In contrast, the inhibition of p27–Hsp90 interaction by geldanamycin (a specific inhibitor of...
Ellman assays determined changes in catalytic properties and inhibitor sensitivity resulting from wild type and mutant rPpAChE1 containing single or combinations of orthologous mosquito mutations. Results Each of the orthologous mutations (F290V, F331W, and G119S) from mosquito AChE significantly ...
and an 80-kDa protein that is a covalent CP dimer. TCV particles can be reassembledin vitrousing CP and either the free RNA or the ribonucleoprotein complex. For both forms of the RNA, the process is selective for viral RNA, and proceeds by continuous growth of a shell from an initiating...
Collectively, these results identify tomatidine as a novel small molecule inhibitor of muscle atrophy. Tomatidine may have utility as a therapeutic agent or lead compound for skeletal muscle atrophy. 展开 关键词: mTOR complex (mTORC), Muscle Atrophy, Skeletal Muscle, Skeletal Muscle Metabolism, ...
using an asparaginase (ASNase). In some of such embodiments the cancer cell has low asparagine synthetase (ASNS) expression. In some of such embodiments the method includes the additional step of reducing glutamine concentration, for example using aminotransferase inhibitor (such as aminooxyacetate)....