Dosage form:oral tablet (15 mg; 30 mg; 45 mg-15 mg; 60 mg-30 mg; 90 mg-30 mg) Drug class:Vasopressin antagonists Medically reviewedby Drugs.com on Dec 12, 2023. Written byCerner Multum. What is tolvaptan? Jynarqueis used to slow the decline in kidney function in adults who haveau...
The initial dosage for JYNARQUE is 60 mg orally per day as 45 mg taken on waking and 15 mg taken 8 hours later. Titrate to 60 mg plus 30 mg then to 90 mg plus 30 mg per day if tolerated with at least weekly intervals between titrations. Patients may down-titrate based on tolerabil...
tolvaptan was started at 45 mg/15 mg which was up-titrated weekly to 60 mg/30 mg and then 90 mg/30mg [20]. There is no published guidance on the optimal titration regimen with varied practices