Autosomal polycystic kidney diseaseTolvaptanUrine outputBackground Few works have analyzed factors associated with urine output in ADPKD patients taking tolvaptan (TVP).Methods We selected 24-h urine samples from ADPKD patients treated with?TVP. Urine osmolality/creatinine ratio was used as estimator of...
Functional characterization of these mutants revealed that R113Q and C192S were normally localized at the basolateral membrane of polarized Madin-Darby Canine Kidney (MDCK) cells and presented proper glycosylation maturation. On the other side, L86P, M272R, and W323_I324insR mutants were ...