Tolterodine belongs to a class ofdrugscalled cholinergic (acetylcholine) receptor blockers. It is used to treat disorders of the urinary bladder that affect urination. The urinary bladder is a muscular "bag." Urine coming from the kidneys fills the bladder and causes it to stretch like a balloo...
Some medications that fall into this class include older tricyclic antidepressants such as doxepin, antihistamines like Benadryl[R] (diphenhydramine), and medications such as Detrol[R] (tolterodine), which treats overactive bladder. Common drugs increase risk of dementia and Alzheimer's have each laun...
Antimuscarinic drugs are the mainstay of pharmacological therapy for OAB / storage LUTS; several studies have demonstrated that tolterodine ER is an effective and well tolerated formulation of this class of treatment. Conclusion Tolterodine ER resulted effective in reducing frequency urgency and nocturia...
Package insert / product label Generic name: tolterodine tartrate Dosage form: tablet, extended release Drug class: Urinary antispasmodicsMedically reviewed by Drugs.com. Last updated on Oct 30, 2024.On This Page Description Clinical Pharmacology Clinical Studies Indications and Usage Contraindications War...
mild to moderate hepatic impairment (Child-Pugh class A or B) severe renal impairment [Creatinine Clearance (CCr) 10–30 mL/min] drugs that are potent CYP3A4 inhibitors Contraindications Urinary retention Gastric retention Uncontrolled narrow-angle glaucoma Known hypersensitivity to the drug or its ...
2 mg capsules taken orally once daily with water and swallowed whole in the presence of: o mild to moderate hepatic impairment (Child-Pugh class A or B) (2.2) o severe renal impairment [Creatinine Clearance (CCr) 10‑30 mL/min] (2.2) o drugs that are potent CYP3A4 inhibitors. (2.2...
Tolterodine, a commercial therapeutic agent for the treatment of overactive bladder, is administered in the form of a film-coated tablet comprising 1 mg, 2 mg or 4 mg of tolterodine L-tartrate to be released in the gastrointestinal tract. With regard to drugs, customers have always asked a ...
Initial in vivo studies demonstrated a functional selectivity for the muscarinic receptors in the urinary bladder over the salivary glands, and subsequent clinical trials showed an overall superior tolerability profile compared with other drugs in the same class (ie, oxybutynin). With immediate- and ...
Relative bioavailability study of tolterodine in healthy human volunteers was done using saliva and plasma matrices in order to investigate the robustness of using saliva instead of plasma as a surrogate for bioavailability and bioequivalence of class III drugs according to the salivary excretion ...