Since the toll-like receptor 4 (TLR4) pathway, an important pathway involved in inflammation induction, has previously been associated with solid tumors, we hypothesized that it would be correlated with the pathophysiological characteristics of AML patients and could be considered as an anticancer ...
Interactive toll-like receptor signaling pathway depicting the activation of innate and acquired immunity, along with an inflammatory response and the up-regulation of cytokines. Targets lead to related information & Tocris products.
进一步的研究探讨。方法:Toll—likereceptor2(TLR2)不仅是激活机体自身免疫防御和炎症反应的重要受体,而且广泛参与多种 细胞功能,包括细胞凋亡。我们使用体外培养的HEK293和高表达TLR2的HEK2932种细胞,以及体外培养小鼠皮层原代神 经元细胞,研究经过吗啡处理后细胞存活率和凋亡的变化,以探讨TLR2信号通路在吗啡诱导的细胞...
The pathogenesis of pancreatitis has long been a hot topic in basic and clinical research but is still not fully clarified.Toll-like receptor 4(TLR4) recognizes the lipopolysaccharide(LPS) of Gram-negative bacteria and stimulates the synthesis and release of inflammatory cytokines through activation of...
In this study, we found that lipopolysaccharide (LPS) and other Toll-like receptor (TLR) agonists activate Nrf2 signaling and the activation is due to the reduction of Keap1, the key Nrf2 inhibitor. TLR signaling-induced Keap1 reduction promoted Nrf2 translocation from the cytoplasm to the ...
关键词:慢性阻塞性肺疾病急性加重期热毒宁注射液TLR4/NF-κB炎症信号通路 DOI: Clinical effect of Reduning injection in treatment of acute exacerbation of chronic obstructive pulmonary disease and its effect on the Toll-like receptor 4/nuclear factor-kappa B inflammatory signaling pathway ...
1. Targeting toll-like receptor signaling pathways for design of novel immune therapeutics. [J] . Hong-Geller E, Chaudhary A, Lauer S Current drug discovery technologies . 2008,第1期 机译:靶向toll样受体信号通路设计新型免疫疗法。 2. Targeting Toll-Like Receptor Signaling Pathways for Design of...
Previous studies have shown that genetic variation in the Toll-like receptor (TLR) signaling pathway is associated with PCa incidence, but any role in progression and mortality is unclear. Among 1,252 PCa cases from the Cancer Prostate in Sweden study, we conducted time-to-event analyses of ...
Recent advances in the field of innate immunity have revealed a complex role of innate immune signaling pathways in both tissue homeostasis and disease. Among them, the Toll-like receptor 4 (TLR-4) pathways has been linked to various pathophysiological conditions, such as cardiovascular diseases (...
2. TLR signaling pathways Stimulation of TLRs triggers the activation of signaling cascades, leading to the induction of immune and pro-inflammatory genes. After ligand binding, TLRs dimerize and undergo conformational changes. This is followed by recruitment to the receptor of TIR-domain-containing ...