3.1.8 Toll-like receptors Toll-like receptors (TLR) are pattern recognition receptors (PRR) that after recognizing and binding to pathogen-associated molecular patterns (PAMP) initiate an immune response. The physiological ligand for TLR-7, coded by TLR7, is single stranded RNA that starts the...
Toll-like receptors (TLRs) activation within the joints has been implicated in pathophysiology of arthritis. However, their role in the genesis of arthritic pain needs to be demonstrated. In the present study, it was addressed the participation of TLR2 and TLR4 and their adaptor molecule MyD88 ...
Systemic bacterial infections are characterized by activation of the innate immune system, initiated by simultaneous recognition of multiple pathogen-associated molecular patterns (PAMPs) and endogenous danger signals by various pattern recognition receptors, such as CD14 and Toll-like receptors (TLRs)1, ...
Innate immune system depends on pattern recognition receptors (PRRs) to detect conserved structures of pathogenic microorganisms (like bacteria, virus, fungus and protozoa), which are called pathogen-associated molecular patterns (PAMPs)9. Toll like receptors (TLRs) play an important role in ...
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11(5):373–84. https://doi.org/10.1038/ni.1863. Article CAS PubMed Google Scholar Weiss DS, Raupach B, Taked...
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fibroblasts and dendritic cells. results a total of 563 putative palmitoylation substrates were identified, more than 200 of which have not been previously suggested to be palmitoylated in past proteomic studies. here we validate the palmitoylation of several new proteins including toll-like receptors ...
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Stimulation by toll-like receptors inhibits osteoclast differentiation. J Immunol. 2002;169:1516–23. Article CAS PubMed Google Scholar Hinck L. The versatile roles of “axon guidance” cues in tissue morphogenesis. Dev Cell. 2004;7:783–93. Article CAS PubMed Google Scholar Kuriyama S, ...
of interferon types associated with the group of 1096 DEGs. Interferome analysis revealed 878 IFN-regulated genes modulated by IFN types I, II, and III, as shown in the Venn diagram.DEGs,differentially expressed genes; IFN, Interferon; IEIs, inborn errors of immunity; TLR, Toll-like receptor...