Human Toll-Like Receptor 4 (hTLR4): Structural and functional dynamics in cancerPAMPs/DAMPsprotein-protein interactionprotein-ligand interactionspecies specificitycomputational drug discoveryToll-Like Receptors (TLRs) recognize a wide variety of pathogen-associated molecular patterns and are centrally involved...
In conclusion, we revealed for the first time that all the components of the LPS receptor complex are expressed in thyroid cells. Evidence that the effects of LPS on rodent thyroid function involve TLR4-induced signaling was obtained. The fact that thyroid cells are able to recognize and ...
近些年来有研究发现Toll样受体4(toll like receptor 4,TLR4)与Nod样受体蛋白3(nod-like receptor family pyrin domain-containing protein 3,NLRP3)炎性小体作为细胞炎症因子可以通过启动天然免疫,刺激相应的信号通路途径产生细胞因子和...
Toll-like receptor 4 (TLR4) is atransmembrane receptorprotein that is highly expressed in the heart and is up-regulated during myocardial I/Rinjury[78]. And TLR4 is involved in the development of MI,DCM, and DOX-CM. For example, previous studies have shown that the levels of TLR4 and...
GJ, de Vries IJ: Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy... Gerty,Schreibelt,Jurjen,... - 《Cancer Immunology Immunotherapy》 被引量: 294发表: 2010年 Toll-Like Receptor 4 Activation in Cancer Prog...
cardiac functionTLR4Paraquat is a nitrogen herbicide imposing severe organ toxicity in human leading to acute lung injury and heart failure. The present study was designed to examine the impact of ablation of the innate proinflammatory mediator toll-like receptor 4 (TLR4) in paraquat-induced cardiac...
showed that systemic injections of monophosphoryl lipid A (MPLA) — a Toll-like receptor 4 agonist that has immunomodulatory properties — reduced Aβ load in the brain and enhanced cognitive function in a mouse model.doi:10.1038/nrd3965Charlotte Harrison...
Early identification of the presence of iron deposits and genetic and environmental triggers that predispose individuals to increased risk of Dox-induced CTX (e.g., overexpression of Toll-like receptor 4 (TLR4)) will enable the early implementation of countermeasure therapy, which will improve the ...
toll like receptor-4 expression in lipopolysaccharide induced lung inflammation histology and histopathology cellular and molecular biology 来自 dx.doi.org 喜欢 0 阅读量: 15 作者:KS Janardhan,M Mcisaac,J Fowlie,A Shrivastav,S Caldwell,RK Sharma,B Singh,B Singh ...
Toll-like receptor 4 (TLR4) plays a key role in the activation of innate immune responses. Loss-of-function mutations in TLR4 prevent diet-induced obesity and insulin resistance (IR). We conducted a population cross-sectional study to evaluate whether Asp299Asp genotype of rs4986790 TLR4 gene ...