Toll-like receptor 3 (TLR3), a pathogen recognition receptor, is stimulated by the viral genomic material double stranded RNA (dsRNA). TLR3 stimulation initiates a signaling cascade that leads to the production of type 1 interferon. Critical to this signaling pathway is a kinase complex, NAP1...
Under normal conditions, the relative expression of Toll-Like-Receptor 1 (TLR-1) between Nan'ao Golden Scallop and brown scallops was statistically insignificant, but was up-regulated under exposure of V. parahaemolyticus, LPS and Poly I:C challenge, indicating the TLR-1 gene involved in anti-...
Toll-like receptors (TLR) are a family of PRR, capable of recognizing and responding to various PAMP. Upon stimulation of the receptor, a cascade of intracellular signaling is initiated, culminating in the activation of NF-κB and secretion of a variety of cytokines, chemokines and expression ...
Toll-like receptor (TLR) signaling is triggered by pathogen-associated molecular patterns that mediate well established cytokine-driven pathways, activating NF-κB together with IRF3/IRF7. In addition, TLR3 drives caspase 8-regulated programmed cell death pathways reminiscent of TNF family death ...
Toll-like receptors (TLRs) have an important role in chronic inflammation in rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, gout and Lyme disease The Toll–IL-1 receptor (TIR) domain triggers biological responses to IL-1 molecules and to TLR ligands Both microbial...
Toll-like receptors (TLRs) are located either on the cell surface or intracellularly in endosomes and their activation normally contributes to the induction of protective immune responses. However, in cancer their activation by endogenous ligands can mod
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Toll-like receptor 1 or other numbers TNF-α: Tumor necrosis factor alpha TRAF6: TNF-receptor-associated factor 6 TRAM: TRIF-related adaptor molecule TRIF: TIR-domain-containing adaptor protein inducing IFN-β VLDL: Very low density lipoprotein ...
Members of the Toll-like receptor (TLR) family play critical roles as regulators of innate and adaptive immune responses. TLRs function by recognizing diverse molecular patterns on the surface of invading pathogens. In the brain, microglial cells generate neuroimmune responses through production of proi...
Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1 eLife, 3 (2014), Article e04066 Google Scholar [39] A. Ishida, K. Akita, Y. Mori, S. Tanida, M. Toda, et al. Negative regulation of Toll-like receptor-4 signaling ...