From a biogenesis standpoint, miRNAs are transcribed in similar fashion to mRNAs encoded by protein coding genes. Their genomic sequence can be found within introns of other genes or can be encoded independently. Once transcribed into primary miRNAs, which can be several hundred base-pairs in lengt...
Product descriptions from the supplier Warning/Disclaimer WARNING: The wire and metal parts of this product can expose you to lead, a chemical which is known to the State of California to cause cancer and birth defects or other reproductive harm. This warning is posted because of the lega...
Yang IA, Barton SJ, Rorke S, Cakebread JA, Keith TP, Clough JB, Holgate ST, Holloway JW (2004) Toll-like receptor 4 polymorphism and severity of atopy in asthmatics. Genes Immun 5:41–45 Article PubMed CAS Google Scholar Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan...
Ankylosing spondylitis is a multifactorial and polygenic inflammatory rheumatic disease with a poorly understood pathophysiology. Apart from HLA, other genes are likely to play a role in disease susceptibility and indigenous bacteria also appear to be involved in the pathology. This suggests that both ...
Stimulation of PBMCs from SLE patients with TLR2 or − 4 agonists triggers more cytokine production as compared to healthy subjects [14]. TLR2 is also increased on CD4+ and CD8+ positive T cells and B cells from SLE patients, which is associated with the increased in-vitro ...
6 [3]. Consequently, TLR4 is endocytosed, which induces MyD88-independent signaling from the TLR4-containing endosomal recycling compartment [4–6], inflicting a type I interferon response that is critical to counter an ongoing infection [7]. Importantly, TLR4 internalization reduces signaling from...
fluorescence intensities from at least three identical experiments normalized to their respective western blots. Values for CD86 or TLR2 co-transfected with GST control were set to 1. DHHC constructs are labeled according to previously used DHHC nomenclature in order to be consistent with past ...
Soares, JB., Pimentel-Nunes, P., Roncon-Albuquerque, R. et al. The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases. Hepatol Int 4, 659–672 (2010). https://doi.org/10.1007/s12072-010-9219-x Download citation Received01 June 2010 Accepted14 September ...