Tolerance to nicotine's disruptive effects on operant responding develops rapidly over a 14-36 day repeated dosing period in both rats and mice. This occurred regardless of whether nicotine was administered pre- or post- to each behavioral exposure. Thus, tolerance development appeared to depend on...
Chronic users of cannabis may experience some withdrawal symptoms when attempting a tolerance break. One study showed thatnearly half of consumers report withdrawal symptomswhen quitting after regular, long-time use. These symptoms are similar to nicotine withdrawal and include irritability, decreased appe...
However, tolerance developed to these effects in rats that had been pre-treated for 6 days with ()-nicotine (0.1 mg/kg/day; subcutaneous). Thus, cross-tolerance to the anxiolytic effects of midazolam develops rapidly following a short period of treatment with a low dose of nicotine, which ...