Immunology Immune unresponsiveness to an antigenic challenge. See Immune tolerance, Self-tolerance Pharmacology An ↑ in dose of a drug required to achieve the same effect in a particular Pt, which is a function of ↑ metabolism–eg, by hypertrophy of the endoplasmic reticulum or ↑ expulsion of...
The definition of drug tolerance in pharmacology is a person's diminished response to a drug over a long-course of the drug's exposure at a certain dose, this mechanism allows the body's physiological processes to adapt to a constantly changing environment. An example of drug tolerance is tak...
Clinical Pharmacology & Therapeutics(2011) Biomarkers of tolerance: searching for the hidden phenotype Esperanza Perucha Irene Rebollo-Mesa Maria P. Hernandez-Fuentes Kidney International Supplements(2011) Nature Reviews Nephrology (Nat Rev Nephrol)ISSN1759-507X(online)ISSN1759-5061(print) ...
In diabetes the hearts exhibit impaired membrane functions, but also increased tolerance to Ca2+ (iCaT) However, neither the true meaning nor the molecular mechanisms of these changes are fully understood. The present study is devoted to elucidation of molecular alterations, particularly those induced...
during their development in the thymus, where they are educated to be self-referential, recognizing peptides bound to self-major histocompatibility complex (MHC) molecules, as well as self-tolerant, meaning that they remain unresponsive to self-peptides displayed on the very same MHC molecules1,2...
1 for vecuronium) in comparison to depolarizing MR or old MR. Meaning that 20 time the MR dose needed for the effect is given IV. This is to have a reserve in deploying the MR effect [35]. Both effect 1 and 2 means in reverse conclusion, that an observed clinical recovery in ...
In diabetes the hearts exhibit impaired membrane functions, but also increased tolerance to Ca2+ (iCaT) However, neither the true meaning nor the molecular mechanisms of these changes are fully understood. The present study is devoted to elucidation of molecular alterations, particularly those induced...