1. Caprioli, R.M., (2019) Imaging Mass Spectrometry: A Perspective.Journal of Biomolecular Techniques Jbt30. 2. Swales, J.G., G. Hamm, M.R. Clench & R.J.A. Goodwin, (2018) Mass spectrometry imaging and its application in p...
当前检测M蛋白的MS方法可分为top-down以及bottom-up MS,top-down MS方法比如miRAMM(monoclonal immunoglobulin Rapid Accurate Mass Measurement)法和MASS-FIX法,两种方法的简介见表2。值得一提的是,梅奥临床实验室在2018年以MASS-FIX法取代了IFE。 表二 ...
Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry (MS) has become a widely used technique for the rapid and accurate identification of bacteria, mycobacteria and certain fungal pathogens in the clinical microbiology laboratory. Thus far, only few attempts have be...
基质辅助激光解吸电离飞行时间质谱(matrix-assisted laser desorption ionization time-of-flight mass spectrometry),MALDI是软电离的原理,一般用来分析生物大分子,比如细菌、病毒、蛋白质、DNA、糖化血红蛋白等,也可以用来做病理切片的质谱成像。 完成MALDI-TOF-MS的步骤都需要人工干预,并且可能非常耗时。对于MALDI点样,样...
MALDI-TOF mass spectrometry can also be employed in the realm of Glycomics, the study of glycans, particularly in glycosylation and glycan structure analysis. The technology's impressive capabilities extend to Lipidomics as well, where it can be used to identify and quantify lipid molecules, encomp...
How to Understand Measurement Uncertainty in TOF Mass Spectrometry and Ion Mobility-Mass Spectrometry
02Time of flight (TOF) mass spectrometry is an important analytical technique. A mixture of three compounds is analysed using a TOF mass spectrometer.The mixture is ionised using electrospray ionisation.The three compounds are known to have the molecular formulas:C3H5O2N C3H7O3N C3H7O2NS0 2....
Methods allowing lipid analysis in a single step are rather scarce. This especially holds if, besides the phospholipid class, also the fatty acid composition is of interest. Although matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) is nowadays an ...
布鲁克rapifleX MALDI-TOF/TOF基质辅助激光解吸电离飞行时间质谱仪rapifleX™可用于测定transport protein OATP2B1,适用于质谱项目。并且参考多项行业标准\。可应用于其他制药/化妆品行业领域。 In this application note, we demonstrate a MALDI MS cellular drug uptake and inhibition assay [1]. It was conducted...
In last decades the matrix-assisted laser desorption/ionizationtime-of-flight mass spectrometry imaging (MALDI-TOF MSI) hasbecome an outstanding tool for detecting spatial distributionof different biomarkers in a variety of tissue samples. Itutilizes the benefits of MALDI-TOF technique, which are rapid...