The complexity of tobacco smoke leads to some confusion about the mechanisms by which it causes lung cancer. Among the multiple components of tobacco smoke, 20 carcinogens convincingly cause lung tumors in laboratory animals or humans and are, therefore, likely to be involved in lung cancer ...
Tobacco Smoke Carcinogens and Lung Cancer 来自 Springer 喜欢 0 阅读量: 113 作者: SS Hecht 摘要: Cigarette smoking is the major cause of lung cancer, the largest cancer killer in the world. This chapter discusses the role of cigarette smoke carcinogens as causes of lung cancer. A general ...
Exposure to tobacco smoke is an established risk factor for lung cancer, although a possible role for genetic susceptibility in the development of lung cancer has been inferred from familial clustering of the disease and segregation analysis. Findings of familial aggregation and statistical evidence for...
Since active smoking causes lung cancer, and since ETS contains many of the carcinogens in tobacco smoke, it can be argued that some causal effect of ETS exposure is to be expected, though this argument depends on there being no threshold dose of exposure. If there is no threshold, what ef...
At several p53 mutational hotspots common to all cancers, such as codons 248 and 273, a large fraction of the mutations are G to T events in lung cancers but are almost exclusively G to A transitions in non-tobacco-related cancers. Two important classes of tobacco smoke carcinogens are the...
Sasco AJ, Secretan MB, Straif K. Tobacco smoking and cancer: a brief review of recent epidemiological evidence. Lung Cancer 2004; 45(Suppl 2):S3. ArticlePubMedGoogle Scholar Hecht SS. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 1999; 91:1194. ...
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S.S. Hecht Tobacco smoke carcinogens and lung cancer J Natl Cancer Inst, 91 (1999), pp. 1194-1210 View in ScopusGoogle Scholar 44 N.L. Benowitz Cigarette smoking and cardiovascular disease: pathophysiology and implications for treatment Prog Cardiovasc Dis, 46 (2003), pp. 91-111 View PDFVi...
作者: Hiroyuki Takahashi and Hisanobu Ogata and Reiko Nishigaki and David H. Broide and Michael Karin 摘要: Summary Chronic exposure to tobacco smoke, which contains over 60 tumor-initiating carcinogens, is the major risk factor for development of lung cancer, accounting for a large portion of ...
Tobacco Smoke Carcinogens and Lung Cancer. Presents information on a mechanistic framework linking nicotine addiction with lung cancer through exposure to carcinogens in tobacco smoke. Pulmonary car... Hecht,S Stephen - 《Jnci Journal of the National Cancer Institute》 被引量: 3006发表: 1999年 Defen...