To perform a proof-of-concept experiment, we chose lysosomes as therapeutic cancer targets13,14,15. Cancer cell lysosomes are hypertrophic and easily ruptured and are more fragile than normal lysosomes16. Lysosomal membrane permeabilization (LMP) can directly trigger cell death by enabling the release...
To perform the experiments, drones, queens, workers and brood combs were obtained from managed honey bee colonies (Apis mellifera L). These colonies were treated each year in September with Amitraz to control Varroa mite pressure. To evaluate the reproductive toxicity of Fipronil on drones, 4 ...
Maternal oxytocin levels rise gradually during pregnancy in response to rising levels of estrogen. Estrogen also increases the numbers and function (binding) of uterine oxytocin receptors in preparation for labour, birth and postpartum transitions [1]. As labour commences, pulses of oxytocin are relea...
Koh LK, Sedrine WB, Torralba TP, et al; Osteoporosis Self-Assessment Tool for Asians (OSTA) Research Group. A simple tool to identify Asian women at increased risk of osteoporosis. Osteoporos Int. 2001;12(8):699-705. doi:10.1007/s001980170070PubMedGoogle ScholarCrossref 26. Richy F, Gou...
Considering this, a new experiment (see CHA_13 in Table 1) under similar conditions to those employed above for the CHA_12 but introducing a small amount of K in the synthesis gel was rationalized (KOH/Si∼0.075, see CHA_13 in Table 1). The crystallization of the pure CHA phase was...
For total proteome analysis, 2 × 106of the pelleted frozen cells were used (Fig.1). The complete workflow, providing an overview of proteome analysis and the sample preparation process, is illustrated in Fig.2. The schematic representation of this workflow was created using BioRender.com....
Preparation of Co-Fe electrodeposits and their performance in relation to oxygen evolution in 40wt% KOH at 70°Cdoi:10.1016/0360-3199(93)90135-WCo/Fe deposits were obtained on nickel substrate in a bath containing dissolved cobalt sulphate, iron nitrate and ammonium citrate at pH 9.8. The ...
Copper(II) sulfate pentahydrate (CuSO4·5H2O), Chromium chloride (CdCl2), Sodium hydroxide (NaOH), Potassium hydroxide (KOH), Cesium hydroxide (CsOH), methanol, Nafion perfluorinated resin solution (5 wt% in a mixture of lower aliphatic alcohols and water) were purchased from Sigma Aldrich....
The reaction solution was prepared with 0.37 volume of the low-molecular weight creatine phosphate tyrosine (LMCPY) mixture [160 mM HEPES-KOH buffer (pH 7.5), containing 4.13 mM tyrosine, 3.47 mM ATP, 2.40 mM each of GTP, CTP, UTP, 0.217 mM folic acid, 1.78 mM cAMP...
Potassium HEDP (K4HEDP) was synthesized by adding 90 g of KOH to an aqueous solution of HEDP previously formed by adding 200 g of water to 108 g of the 60 weight % aqueous solution of HEDP under stirring. The obtained clear solution had a pH of 12.0 and a concentration of K4HEDP of...