Mitigating the problem of unclear TNK dosing has prevented dosing errors for acute ischemic stroke and myocardial infarction as well as the negative outcomes associated with a medication error involving a high-alert medication.Marlies MeinholdJefferson Einstein Med Cntr, Philadelphia, PATheresa DiFranco...
The FDA has received reports of 21 cases of medication errors associated with TNKase between October 2000 and June 2014. In one case, the error involved a stroke patient who was mistakenly given TNKase instead of the intended Activase. This was attributed to a nursing error and confusion betwe...
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8. Shigemura K, Tanaka K, Yasuda M, et al. Efficacy of 1-day prophylaxis medication with fluoroquinolone for prostate biopsy. World J Urol. 2005; 23(5):356–360. 9. Sabbagh R, McCormack M, Péloquin F, et al. A prospective randomized trial of 1-day versus 3-day antibiotic prophyl...
Weight-optimized TNK-tPA dosing requires body weight estimation, which may introduce the potential for medication error. However, data from TNK-tPA clinical trials suggest that body weight estimates can err by up to 20 kg (44 lb) without an increased risk of ICH or death. Furthermore, the ...