16.De A, Dainichi T, Rathinam CV, Ghosh S. The deubiquitinase activity of A20 is dispensable for NF-kappaB signaling. EMBO Rep. 2014;15(7):775-83. 17.Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, et al. Dimerization and ubiquitin mediated recruitment of A20, a comple...
http://16.DeA, Dainichi T, Rathinam CV, Ghosh S. The deubiquitinase activity of A20 is dispensable for NF-kappaB signaling. EMBO Rep. 2014;15(7):775-83. 17.Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, et al. Dimerization and ubiquitin mediated recruitment of A20, a...
16.De A, Dainichi T, Rathinam CV, Ghosh S. The deubiquitinase activity of A20 is dispensable for NF-kappaB signaling. EMBO Rep. 2014;15(7):775-83. 17.Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, et al. Dimerization and ubiquitin mediated recruitment of A20, a comple...
In addition, TNFα significantly increased the phospho- rylation of the PI3K, AKT, ERK, and NF-κB signaling pathways. Notably, treatment with curcumin (CUR, diferuloylmethane), an anti-inflammatory polyphenol, significantly increased the expression of dysregulated miRNAs in EESC in a dose-...
Tumor necrosis factor (TNFα) is a cytokine involved in Ang II signaling and promotes the inflammatory response via NF-kB. We hypothesized that activation of AT2 prevents TNFα stimulation of intercellular adhesion molecule-1 (ICAM-1) expression in human coronary artery endothelial cells (HCREC) ...
Cell Stress Chaperones Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways PubMed: 26577463 Diabetes Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin ...
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Pubmed:24962643 Archives of Oral Biology Hyperlipidemia causes changes in inflammatory responses to periodontal pathogen challenge: Impli...
Inhibition of TNF receptor signaling by anti-TNFα biologicals primes naïve CD4(+) T cells towards IL-10(+) T cells with a regulatory phenotype and function. Clin Immunol. 2014;151:136–45. https://doi.org/10.1016/j.clim. 2014.02.008. 24. Bouzgarrou ...
晚期糖化终产物通过p38MAPK、JNK、NF.KB途径促进T淋巴细胞分泌TNF-a中文摘要目的:研究表明晚期糖化终产物(AGEs)与糖尿病加速动脉粥样硬化(AS)形成有密切关系。研究发现AGEs可影响内皮细胞、单核巨噬细胞、平滑肌细胞表达炎症因子,使细胞功能紊乱,参与AS的形成。而AGEs对T细胞功能影响的研究较少,T细胞的激活与炎症因子...
NF-κB signaling pathway3. Mutant, truncated A20 proteins are likely to act through haploinsufficiency because they do not exert a dominant-negative effect in overexpression experiments. Patient-derived cells show increased degradation of IκBα and nuclear translocation of the NF-κB p65 subunit ...