[1]. Zelová H, et al. TNF-α signalling and inflammation: interactions between old acquaintances. Inflamm Res. 2013 Jul;62(7):641-51. [2]. Horiuchi T, et al. Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents. Rheumatology (Oxford). 2010 Jul;49(7):121...
FunctionThe main function of TNF Alpha is to regulate the immune cells. It has the ability to induce a fever, speed up cell death, create inflammation, and so much more. TNF is released in vast quantities when bacterial products such as lipopolysaccharide and interleukin-1 are present. It wo...
rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [...
Protection from obesity-induced insulin resistance in mice lacking TNF-Alpha function.Discusses research which investigated the role of tumor necrosis factor TNF-Alpha in obesity and insulin resistance in mice. Molecular basis of obesity and insulin resistance; Results when TNF-Alpha is absent; TNF-...
Tumor necrosis factor-α (TNF-α) is a pleiotropic factor exhibiting antitumor effects, alters endothelial barrier function, reduces tumor interstitial pressure and mediates immune responses. TNF-α is associated with a number of cell signalling events, associated with cell necrosis and apoptosis, and...
differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]...
Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections...
Sertoli cells have long been considered to be involved in the regulation of the immune response in the testis. More recently, the Fas system has been implicated in the maintenance of the immune privilege in the testis as well as in the regulation of germ cell apoptosis. However, the control...
Protection from obesity-induced insulin resistance in mice lacking TNF-Alpha function. Discusses research which investigated the role of tumor necrosis factor TNF-Alpha in obesity and insulin resistance in mice. Molecular basis of obesity and... Uysal,K.,Teoman,... - 《Nature》 被引量: 3473发...
Presta LG (2006) Engineering of therapeutic antibodies to minimize immunogenicity and optimize function. Adv Drug Del Rev 58:640–656 Ramos-Casals M, Brito-Zenon P, Munoz S et al (2007) Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases. Medicine 86:242–251 ...