Elevated levels of TNF-伪 associated with RBM10 overexpression resulted from increased TNF-伪 transcription, not TNF-伪 mRNA stabilization. These results suggest that RBM10 has the ability to mo...
Our results demonstrated that IL-27 induced and synergized with TNF-伪 to up-regulate CXCL10 mRNA and protein concentrations in a steroid-insensitive manner. This synergistic CXCL10 production was dependent on the transcriptional regulation of CXCL10 gene promoter activity and the enhanced stability ...
For this purpose, IL-1β and TNF-α mRNA expression was determined by RT-PCR in the hippocampus of rats administered once, or for seven consecutive days with sertraline at a low dose (0.75 mg/kg). The effect of sertraline at dos...
ChIP and Luciferase assays show that TNF-α inhibits CRE to inhibit SNAT2 mRNA transcription.When taken together along with Kinetics, Western blotting, immunocytochemistry, and qRT-PCR demonstrated that TNF-α transcriptionally inhibits SNAT2 via CRE in IEC-6 cells. Thus, this study provides new ...
Further, in silico modeling was done to predict secondary structure of mRNA for g.鈥鈥T鈥gt;鈥塆 polymorphism in the ADIPOQ gene by RNA fold. Results: The minor allele frequency observed in the controls for the TNF-伪 G鈥gt;鈥堿 and ADIPOQ T鈥gt;鈥塆 polymorphisms were 0.07 and 0.10,...
We found that SalB, as well as NADPH oxidase inhibitors, DPI or apocynin, and antioxidant NAC, inhibited TNF-伪-induced MMP-2 mRNA, protein expression, and gelatinolytic activity in HASMCs in a concentration-dependent manner. We also observed a dose-dependent decrease in ROS production and ...
Moreover, T0901317, a LXR agonist, significantly increased the ABCG1mRNA expression by 3 times when 5?μg/ml T0901317 treated HUVECs for 24?h. With upregulation of ABCG1, decreased NOS activity induced by TNF-α was reversed about 47%, and concomitant NO levels was reversed by 30% ...