STAT1-deficiency in U3A cells counteracts tmTNF-α-induced DISC formation and apoptosis. Conversely, reconstitution of STAT1 expression restores tmTNF-α-induced apoptotic signaling in the cell line. Consistently, tmTNF-α suppresses the growth of STAT1-containing HT1080 tumors, but not of STAT1-...
Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules. Antioxidants (Basel), 2024, 13(12)1533 Front Cell Infect Microbiol, 2023, 13:1128000 Front Pharmacol, 2021, 12:656697 S3865 Taurochenodeoxycholic acid Taurochenodeoxycholic acid (Taurocheno...
Proinflammatory Cytokines IL-6 and TNF-alpha Increased Telomerase Activity through NF-kappa B/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signal... There are increasing evidences of proinflammatory cytokine involvement in cancer development. Here, we found that two cytokines, IL-6 and TNF...
P162 Ciliary neurotrophic factor protects mice against type 1 diabetes and interleukin-1B-induced beta-cell apoptosis through SOCS3 expression: Role of stat1/stat3 balance in cytokine- induced iNOS-dependent beta-cell death Type 1 Diabetes (DM1) is characterized by a cytokine-dependent loss of pan...
IFN-gamma inhibits cytoprotective NF-kappa B through STAT1/IRF-1 pathways J Biol Chem, 276 (2001), pp. 13153-13159 View PDFView articleView in ScopusGoogle Scholar 18 A.G. Wilson, J.A. Symons, T.L. McDowell, H.O. McDevitt, G. Duff Effects of a polymorphism in the human tumor ...
Defective TNF-alpha-induced apoptosis in STAT1–null cells due to low constitutive levels of caspases. Science 278: 1630–1632.Kumar A, Commane M, Flickinger TW, Horvath CM and Stark GR (1997) Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of ...
696 MAPK inhibition synergizes with TNF-alpha to promote the expression of STAT1, IRF-1 and MHC class Idoi:10.1016/j.jid.2020.03.708B.P. PollackY. ChangElsevier BVJournal of Investigative Dermatology
Suk K,Kim S,Kim YH,et al.IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death. Journal of Immunology . 2001Suk K, Kim S, Kim YH et al. (2001) IFN-g/TNF-a syner- gism as ...
In parallel, an increase in intracellular STAT1 reservoir led to amplification of IFN-induced STAT1 activation (Fig. 3). Conclusions Our study reveals a novel pathogenic function of TNFα, namely prolonged and gene-specific priming of FLS for enhanced transcription of inflammatory chemokines due to ...
Stimulatory effect of TNF-alpha on KGA expression was reduced by selective inhibition of (STAT3) but not by inhibition of STAT1 nor nuclear transcription factor kappa. Additionally, the role of miRNA in TNF alpha induced expression of KGA in astrocytes was excluded, since the expression of miR...