(TNF alpha), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4+ T cells. TN alpha has cytolytic activity against a range of tumor cells and is important in immune regulation. TNF alpha forms dimers and trimers and also exists as a 26 kDa membrane bound ...
肿瘤坏死因子alpha(TNF-α)抑制剂的作用机制 肿瘤坏死因子alpha(TNF-α) 是一种可溶性 157 个氨基酸的蛋白质 (17.4 kDa),对应于全长跨膜蛋白的 C 端胞外结构域,可由多种细胞分泌,包括脂肪细胞、活化的单核细胞、巨噬细胞、B细胞、T细胞和成纤维细胞。它属于 TNF 配体家族,通过两种受体 TNFR1 和 TNFR2 发...
M.W 38.44 kDa. S3261 Myrislignan Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan inhibits interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). Myrislignan significantly inhibits the expressions of inducible NO synthase (...
TNF-alpha binds the ubiquitous 55-60 kDa TNF RI (19, 20) and the hematopoietic cell-restricted 78-80 kDa TNF RII (21, 22), both of which are also expressed as homotrimers (1, 23). Both type I and type II receptors bind TNF-alpha with comparable affinity and can promote NFkB acti...
TNF-alpha binds the ubiquitous 55-60 kDa TNF RI (20, 21) and the hematopoietic cell-restricted 78-80 kDa TNF RII (22, 23), both of which are also expressed as homotrimers (1, 24). Both type I and type II receptors bind TNF-alpha with comparable affinity and can promote NF kappa...
Additional bands at: 28 kDa (possible glycosylated form), 50 kDa, 75 kDa. We are unsure as to the identity of these extra bands.Exposure time: 2 minutesMature THP-1 and Raw264.7 cells were treated with LPS (1 ug/ml)for 6 hours to stimulate production of TNF alpha. Brefeldin A (300...
分子量 21 kDa Uniprot ID P01375 适用种属 Human, Mouse, Rat 验证应用 ELISA, WB, IHC 建议稀释比例 WB: 1:1000 - 1:2000; IHC: 1:50 - 1:100 图片 Immunohistochemistry of paraffin-embedded human stomach tissue slide using FNab09822( TNF-a Antibody) at dilution of 1:100. Hela cells we...
Cleavage of membrane bound TNF-alpha by TACE/ADAM17 releases a 55 kDa soluble trimeric form of TNF-alpha (6, 7). TNF-alpha trimers bind the ubiquitous TNF RI and the hematopoietic cell-restricted TNF RII, both of which are also expressed as homotrimers (1, 8). TNF-alpha regulates ...
Recombinant human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein. Tumor Necrosis Factor,TNFSF2,Cachectin,Differentiation-inducing factor (DIF),Necrosin,Cytotoxin 保存条件: RT 说明书地址: 点击查看详细...
The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer (4). Ligation of this complex induces reverse signaling that promotes lymphocyte co-stimulation but diminishes monocyte responsiveness (5). Cleavage of membrane bound TNF-alpha by TACE/ADAM...