背景:促炎因子在生理和病理条件下都可调节中枢神经系统的功能.正常生理条件下TNF-α的含量较低,促进大脑发育,调节兴奋性氨基酸受体通路和突触强度.在疾病状态下,TNF-α的含量增至正常生理条件下的40倍.然而,考虑到在一些疾病发展过程中TNF-α含量的巨大改变,TNF-α调节突触可塑性,神经突触生长和情绪-焦虑相关的行为...
TNF-alpha has cytolytic activity against a range of tumor cells and is important in immune regulation. TNF-alpha forms dimers and trimers and also exists as a 26 kDa membrane bound form.Applications Reported: The Mab1 antibody has been reported for use in ELISA, ELISPOT, intracellular staining...
(TNF-alpha), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4^+ T cells. TNF-alpha has cytolytic activity against a range of tumor cells and is important in immune regulation. TNF-alpha forms dimers and trimers and also exists as a 26 kDa membrane ...