两个受体膜内部分最主要的区别在于TNFR1上面有一个死亡区域，TNFR2上没有，这一死亡区域是一段约70个氨基酸的序列，这一区域对TNF-α启动的细胞凋亡是必须的。与Fas蛋白的死亡区域相似，这一细胞内的区域是种附属信号蛋白的结合位点，这些蛋白包括Fas相关死亡区段结合蛋白（FADD），TNFR-1相关死亡区段...
Tumor Necrosis Factor beta Entrez Gene IDs 4049 (Human); 16992 (Mouse) Alternate Names LT; LTA; LT-alpha; lymphotoxin alpha (TNF superfamily, member 1); Lymphotoxin alpha; Lymphotoxinalpha; Lymphotoxin-alpha; tnfb; TNF-beta; TNFBlymphotoxin-alpha; TNFSF1; TNFSF1B; TNFSF1TNF-beta; tumo...
and rat TNF-alpha. TNF-alpha is produced by a wide variety of immune, epithelial, endothelial, and tumor cells. TNF-alpha is assembled intracellularly to form a noncovalently linked homotrimer which is expressed on the cell surface. Cell surface TNF-alpha can induce the lysis of neighboring ...
Purified anti-human LT-α (TNF-β) Antibody - Lymphotoxin-α (LT-α), also known as tumor necrosis factor-beta (TNF-β), is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other tar
Quantitative analysis of the TNF-alpha-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKbeta substrate. Nat Commun 2015; 6: 6658. 35 Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W et al. Osmotic stress- induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep ...
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Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis. J. Infect. Dis. 196, 853–860 (2007). Article CAS PubMed Google Scholar Ruby, J., Bluethmann, H. & Peschon, J. J. Antiviral activity of tumor ...
ofgenesofCOX-2.NOS-2andMMP 一9inratIL,1beta—in— ducedandTNF-alpha—inducedchondrocytes[J].Osteoarthritis Cartilage,2006,4(4):367—376. (本文编辑:詹道友)[收稿日期]2012—01—31 (上接403 页) 类药物即可控制餐后血糖,又可减少因胰岛素分泌 ...
alpha and TNF‑ beta /lymphotoxin. Each subunit contains four TNF‑ alpha trimer-binding cysteine-rich domains (CRD) in its extracellular domain (ECD) (1‑6). TNF-alpha binding to TNF R1 induces the sequestration of TNFRI in lipid rafts, where it activates NF kappa B and is cleaved...
TNF RI occurs both in membrane bound and soluble forms and functions as a receptor for TNF-alpha and TNF-beta. In the superfamily nomenclature, it is designated TNFRSF1A. Long Name Tumor Necrosis Factor Receptor I Entrez Gene IDs 7132 (Human); 21937 (Mouse); 25625 (Rat); 102135285 (Cynom...