Kinetic analysis of TNF-alpha oligomer- monomer transition by surface plasmon resonance and immunochemical methods. Cytokine. 1993; 5(6):539-545. [PubMed: 8186365]Poiesi C, Albertini A, Ghielmi S, Cassani G, Corti A (1993) Kinetic analysis of TNF-[alpha] oligomer-monomer transition by ...
It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types ...
It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types ...
TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane-bound protein and free soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced...
Recombinant Human TNF-alpha (HEK293-expressed) Protein SEC-MALSRecombinant human TNF-alpha (Catalog # 10291-TA) has a molecular weight (MW) of 52.3 kDa as analyzed by SEC-MALS, suggesting that this protein is a homotrimer. MW may differ from predicted MW due to post-translational modificatio...
Tumour necrosis factor-alpha (TNF-α) is a multi-functional cytokine that can regulate many cellular and biological processes such as immune function, cell differentiation, proliferation, apoptosis and energy metabolism. It is synthesised as a 26-kDa transmembrane monomer (mTNF-α) [1] that underg...
Tumor Necrosis Factor Alpha (TNF-α) is a pleiotropic pro-inflammatory cytokine. It act as central biological regulator in critical immune functions, but its dysregulation has been linked with a number of diseases. Inhibition of TNF-α has considerable t
Myxoma virus T2 protein, a tumor necrosis factor (TNF) receptor homolog, is secreted as a monomer and dimmer that each bind rabbit TNF alpha, but dimmer is more potent TNF inhibitor J. Biol. Chem., 271 (1996), pp. 13333-13341 View PDFView articleView in ScopusGoogle Scholar [41] A....
Freshly prepared serial dilutions of mouse recombinant α-synuclein monomer were loaded as standards. The antibodies used in this study are listed in Supplementary Table 4. TNF-α levels were measured using a Mouse TNF-alpha Quantikine ELISA Kit (SMTA00B; R&D Systems, Minneapolis, MN, USA) ...
Tumour necrosis factor alpha (TNFα, also known as cachectin), is a naturally occurring mammalian cytokine produced by numerous cell types, including monocytes and macrophages in response to endotoxin or other stimuli. TNFα is a major mediator of inflammatory, immunological, and pathophysiological rea...