The JIA approval marked the sixth approved indication for the biologic therapy that works by blocking the tumor necrosis factor alpha (TNF-alpha). Adalimumab also indicated to treat certain patients with ankylosing spondylitis, Crohn's disease, chronic plaque psoriasis, p...
Adalimumab biosimilar、adalimumab + [1] 靶点 TNF-α 作用方式 抑制剂 作用机制 TNF-α抑制剂(肿瘤坏死因子α抑制剂) 治疗领域 免疫系统疾病感染消化系统疾病+ [3] 在研适应症 葡萄膜炎化脓性汗腺炎强直性脊柱炎+ [6] 非在研适应症 中轴性脊柱关节炎小儿克罗恩病 ...
Foeldvari I, Neilsen S, Kummerle-Deschner J et al (2007) Tumor necrosis factor-alpha blocker in treatment of juvenile-idiopathic arthritis-associated uveitis refractory to second-line agents: results of a multinational survey. J Rheumatol 34:1146–1150 CASPubMedGoogle Scholar Foster SC, Tufail ...
Good clinical response, remission, and predictors of remission in rheumatoid arthritis patients treated with tumor necrosis factor-alpha blockers: the GISEA study. J Rheumatol. 2007;34:1670–3. CAS PubMed Google Scholar Potter C, Hyrich KL, Tracey A, et al. Association of rheumatoid factor ...
b, Production of O2−, in relative luminescence units (RLU), by GM-CSF-matured MDMs from healthy controls treated with adalimumab or isotype control, stimulated as in (a). Representative data from n = 3 independent experiments are shown. Bottom: AUC analysis of O2− production by ...
Infliximab and adalimumab are monoclonal antibodies to TNF, whereas etanercept is a dimeric, soluble recombinant protein of the extracellular domain of human p75 TNF receptor fused to the Fc fragment of human IgG1. All three agents bind to TNF, but important differences exist between them in terms...
TNF blockers Anti-tumor necrosis factor These drugs include: Adalimumab (Humira), adalimumab-atto (Amjevita) Certolizumab pegol (Cimzia) Etanercept (Enbrel), etanercept-szzs (Erelzi) Golimumab (Simponi, Simponi Aria) Infliximab (Remicade), infliximab-dyyb (Inflectra) ...
Also, infliximab, adalimumab, and golimumab can induce apoptosis of cells that produce TNF-alpha, but etanercept and certolizumab pegol cannot. Although these differences have been elucidated, the full impact on clinical outcomes has yet to be determined.6 The variations among the TNF inhibitors ...
Also, infliximab, adalimumab, and golimumab can induce apoptosis of cells that produce TNF-alpha, but etanercept and certolizumab pegol cannot. Although these differences have been elucidated, the full impact on clinical outcomes has yet to be determined.6 The variations among the TNF inhibitors ...
Einzelfallberichte sprechen für eine gute Wirksamkeit von TNF-alpha-Antagonisten. E ine Studiengruppe der Karls-Universität in Prag prüfte den Effekt von Adalimumab bei schwerer hartnäckiger Acne inversa (Syn.: Hidradenitis suppurativa). Acht Patienten, die seit über fünf Jahren an der ...