NLRP3 inflammasomeNF-kappa BDeposition of amyloid-beta in Alzheimer's disease is accompanied by chronic inflammation, which involves raised levels of pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1 beta. However, the role of A beta(1-42) in the inflammatory process, before it gets ...
Muscone significantly downregulats the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6). Ecotoxicol Environ Saf, 2025, 292:117961 J Pharm ...
NLRP3重组蛋白;高活性/Recombinant human NLRP3 protein LIMCH1重组蛋白;高活性/Recombinant human LIMCH1 protein CDKN2A重组蛋白;高活性/Recombinant human CDKN2A protein Ntn1重组蛋白;高活性/Recombinant human Ntn1 protein PER1重组蛋白;高活性/Recombinant human PER1 protein PER2重组蛋白;高活性/Recombinant human...
AuthentiKine™ Human TNF-alpha ELISA Kit from Proteintech (96 tests) . Quantitate AuthentiKine™ Human TNF-alpha in Serum, Plasma, Cell culture supernatant, Urine. Cat.No. KE00154.
[23]. In our study we found a trend for associations of the variant allele ofNLRP3(rs4612666) with increased risk of AS (p = 0.06). However, our results are in contrast to a meta-analysis of thePTPN22(rs2476601) polymorphism that did not find an association with AS [34]. ...
Carvedilol attenuates inflammatory reactions of lipopolysaccharide-stimulated BV2 cells and modulates M1/M2 polarization of microglia via regulating NLRP3,... Microglial cells coordinate immune responses in the central nervous system. Carvedilol (CVL) is a non-selective β-blocker with anti-inflammatory ...
In INS-i cells, with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inhibitor pretreatment, As2O3-induced activation of pyroptosis was decreased; with tumor necrosis factor-alpha (TNF-alpha) inhibitor pretreatment, As2O3-induced activation of NLRP3 inflammasome and pyroptosis were ...
Moreover, the inflammatory cytokine TNF‐α increased CM‐EV secretion through a process involving NLRP3 inflammasome activation and mTOR signalling. Here, we detailed for the first time the regulatory mechanisms of EV biogenesis in hiPSC‐CMs upon MI‐associated stressors.Viola, Margarida...
In contact-dependent co-cultures, FO reduced inflammatory (IL-6, TNFα, IFN-γ) and macrophage chemotactic (CCL2, CCL7, CCL3) mRNA expression and/or secreted protein, NF-κB p65 activation, ROS accumulation, NLRP3 inflammasome priming (Nlrp3, Il1β mRNA) and activation (caspase-1 ...
Extracellular Ca2 + is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors Nat. Commun., 3 (2012), p. 1329 View in ScopusGoogle Scholar [24] C.L. Tu, W. Chang, D.D. Bikle Phospholipase cgamma1 is required for activation of store-operat...