Th1 cells are chemokine receptor CXCR3+ lymphocytes bearing the T-box expressed in T cells (T-bet) transcription factor, secrete interferon (IFN)-γ, tumor necrosis factor (TNF)-α and interleukin (IL)-2, and eradicate intracellular pathogens; conversely, Th2 lymphocytes express GATA-3 ...
Effector function of diabetogenic CD4 Th1 T cell clones: a central role for TNF-alpha. J. Immunol. 175, 7738-7745 Effector function of T cells in autoimmune diabetes has been widely studied with mixed populations of lymphoid T cells stimulated ex vivo, but this approac... J Cantor,K ...