表1 ICIs在a/mTNBC中当前和即将进行的临床试验 1. Howlader N, Altekruse SF, Li CI, et al. US Incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status. J Natl Cancer Inst. 2014;106(5):dju055. 2. Danzi...
17. Wolf DM, Yau C, Campbell MJ, et al. Biomarkers predicting response to 5 immunotherapy arms in the neoadjuvant I-SPY2 trial for early-stage breast cancer (BC): evaluation of immune subtyping in the response predictive subtypes (RPS)...
[1]中国抗癌协会乳腺癌专业委员会(CBCS)和中华医学会肿瘤学分会乳腺肿瘤学组(CSOBO)乳腺癌诊治指南与规范精要本(2025年版) [2]Jiang YZ, Ma D, Suo C, et al. Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies. Cancer Cell. 2019;35(3):428-44...
[1]中国抗癌协会乳腺癌专业委员会(CBCS)和中华医学会肿瘤学分会乳腺肿瘤学组(CSOBO)乳腺癌诊治指南与规范精要本(2025年版) [2]Jiang YZ, Ma D, Suo C, et al. Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies. Cancer Cell. 2019;35(3):428-44...
Jiang Y Z, Ma D, Suo C, et al. Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies. Cancer Cell, 2019, 35(3): 428-440.e5. 左泽锦, 田廷伦, 罗婷. 乳腺癌免疫治疗进展. 华西医学, 2023, 38(11): 1766-1769. ...
TNBC molecular subtypes exhibit heterogeneous mutational profiles 为了更深入地了解驱动这种异质性的潜在基因组异常,研究人员评估了靶向和全外显子组测序得出的TNBC分子亚型的突变情况。 在447例可用数据中,鉴定了2273个体细胞突变,包括1994个点突变和279个indels。LAR亚型的突变负担显著较高,而MSL亚型的突变负担显著较...
TNBC molecular subtypes exhibit heterogeneous mutational profiles 为了更深入地了解驱动这种异质性的潜在基因组异常,研究人员评估了靶向和全外显子组测序得出的TNBC分子亚型的突变情况。 在447例可用数据中,鉴定了2273个体细胞突变,包括1994个点突变和279个indels。LAR亚型的突变负担显著较高,而MSL亚型的突变负担显著较...
[2]Jiang YZ, Ma D, Suo C, et al. Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies. Cancer Cell. 2019;35(3):428-440.e5. doi:10.1016/j.ccell.2019.02.001 [3]Yang F, Xiao Y, Ding JH, et al. Ferroptosis heterogeneity in triple-neg...
[2]Jiang YZ,Ma D,Suo C,et al.Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers:Subtypes and Treatment Strategies.Cancer Cell.2019;35(3):428-440.e5.doi:10.1016/j.ccell.2019.02.001 [3]Yang F,Xiao Y,Ding JH,et al.Ferroptosis heterogeneity in triple-negative breast cancer...
发表于:Clin Cancer Res. 2015 Apr文章题目是:Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-negative Breast Cancer 主要是考虑到TNBC是异质性较大的一种乳腺癌,而且预后非常差,所以临床用药指导急需对TNBC本身更加细致的分类,研究团队通过贝勒医学院分两次 收集了 198个TNBC病人, (...