Lehmann 等人首先将三阴性乳腺癌(TNBC) 分为6类: Basal-like 1 (BL1) basal-like 2 (BL2) immunomodulatory (IM) mesenchymal (M) mesenchymal stem-like (MSL) luminal androgen receptor (LAR) 后又重新修正为4类: basal-like/immune-suppressed (BLIS) basal-like/immune activated (BLIA) luminal androgen...
normal-like 当然,PAM50的分类也是可以的。 其中 表达量得到的basal-like 亚型和 IHC得到的TNBC 有重合,但并不等价。 而在2011就把TNBC分类过,如下: 1) androgen receptor positive 2) claudin-low-enriched mesenchymal 3) mesenchymal stem-like 4) immune response two cell cycle-disrupted basal subtypes 5)...
另外还有一些名称可以表达这类乳癌,如基底样型乳腺癌(Basal-like breast cancer),这是需要通过基因表达谱检测并进行聚类后分出的乳腺癌亚型,目前国内各大医院病理科几乎做不到,一是成本高,二是分析上还是有难度。所以临床实践中最为常用的分类手段还是IHC,通常用这几个抗体:ER、PR、HER2,外加Ki67,以明确细胞增殖...
claudin-low normal-like 当然,PAM50的分类也是可以的。其中表达量得到的basal-like亚型和IHC得到的TNBC有重合,但并不等价。 而在2011就把TNBC分类过,如下: androgen receptor positive claudin-low-enriched mesenchymal mesenchymal stem-like immune response two cell cycle-disrupted basal subtypes BL-1 and BL-2...
首先是2011的meta分析,J Clin Invest.2011 Jul;把TNBC分成6类:Basal-like 1 (BL1), basal-like 2 (BL2), immunomodulatory (IM), mesenchymal (M), mesenchymal stem-like (MSL) and luminal androgen receptor (LAR) 然后同样的作者,PLoS One.2016 Jun 16,发文重新修订了 之前的分类,变成4类: (TNBCtype...
另外还有一些名称可以表达这类乳癌,如基底样型乳腺癌(Basal-like breast cancer),这是需要通过基因表达谱检测并进行聚类后分出的乳腺癌亚型,目前国内各大医院病理科几乎做不到,一是成本高,二是分析上还是有难度。所以临床实践中最为常用的分类手段还是IHC,通常用这几个抗体:ER、PR、HER2,外加Ki67,以明确细胞增殖...
首先是2011的meta分析,J Clin Invest. 2011 Jul;把TNBC分成6类:Basal-like 1 (BL1), basal-like 2 (BL2), immunomodulatory (IM), mesenchymal (M), mesenchymal stem-like (MSL) and luminal androgen receptor (LAR) 然后同样的作者,PLoS One. 2016 Jun 16;发文重新修订了 之前的分类,变成4类:(TNBCtyp...
首先是2011的meta分析,J Clin Invest.2011 Jul;把TNBC分成6类:Basal-like 1 (BL1), basal-like 2 (BL2), immunomodulatory (IM), mesenchymal (M), mesenchymal stem-like (MSL) and luminal androgen receptor (LAR) 然后同样的作者,PLoS One.2016 Jun 16,发文重新修订了 之前的分类,变成4类: (TNBCtype...
首先是2011的meta分析,J Clin Invest. 2011 Jul;把TNBC分成6类:Basal-like 1 (BL1), basal-like 2 (BL2), immunomodulatory (IM), mesenchymal (M), mesenchymal stem-like (MSL) and luminal androgen receptor (LAR) 然后同样的作者,PLoS One. 2016 Jun 16;发文重新修订了 之前的分类,变成4类:(TNBCtyp...
另外还有一些名称可以表达这类乳癌,如基底样型乳腺癌(Basal-like breast cancer),这是需要通过基因表达谱检测并进行聚类后分出的乳腺癌亚型,目前国内各大医院病理科几乎做不到,一是成本高,二是分析上还是有难度。所以临床实践中最为常用的分类手段还是IHC,通常用这几个抗体:ER、PR、HER2,外加Ki67,以明确细胞增殖...