Then the mechanism of RITA and TMZ treating GBM were further studied by detecting the expression of the proteins associating with p53 pathway, such as ASK1, Bax, and so on. RITA bound to the amino acids residues in the activation domain of the ASK1, then induced the conformation change of...
For the in vitro studies, cell growth, IC50 values, RNA-seq, RT-PCR, and ELISA were used to assess growth inhibition, possible mechanism-of actions (MOAs) associated with combined OKN-007 + TMZ versus TMZ alone, and gene and protein expression levels, respectively. Microarray analysis ...
A team of scientists from Virginia Tech Carilion Research Institute and clinicians from Carilion Clinic may have found a way to increase sensitivity to the front-line chemotherapeutic agent temozolomide (TMZ) in glioblastoma (GBM), even after resistance.
Bortezomib, a proteasome inhibitor, has been approved for the treatment of multiple myeloma but its use in glioma awaits further investigation. This study aimed to explore the chemotherapeutic effect and the underlying mechanism of bortezomib on gliomas. Methods U251 and U87 cell viability and ...
2002年至今,浙大沈立荣教授已在本刊发表13篇研究论文,涉及蜂王浆主蛋白的抗衰老作用及机制研究、蜂王浆抗菌肽基因相关作用机制的研究、以内源性特异性蛋白为标记物的蜂蜜真伪鉴别技术研究与快速检测试剂开发等,本集含6篇。
The Carbon Emission Mechanism of Traffic Congestion in Mega Cities Caused by Job-housing Imbalance: A Case Study of Commuting Behavior from Suburban Housing to Urban Workplaces in Tianjin 王 睿 柯 嘉 张 赫 摘要:以天津市为例,采用早晚高峰OD...