Compared with U251 cells, U87 cells demonstrated more severe cell apoptosis and cell cycle arrest when under the same drug concentration. This was in accordance with the intenser cytotoxicity of bortezomib in U87 as mentioned above. Fig. 1 Effects of bortezomib on the proliferation, apoptosis, ...
Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D et al (in press) DNA methylation-based classification of human central nervous system tumours. Nature Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA et al (2016) Molecular profiling reveals biologically...
The resistance of GBM to the drug is currently the subject of work by specialists in the field of oncology, and its use in various regimens and patient groups may bring therapeutic benefits in the future. The aim of this review paper is to summarize the relevance of TMZ in the treatment ...