TMPO-AS1miR-98-5pBCAT1Background and Aim Colorectal cancer, as a common malignant carcinoma in the gastrointestinal tract, has a high mortality globally. However, the specific molecular mechanisms of long non‐coding RNA (lncRNA) thymopoietin antisense transcript 1 (TMPO‐AS1) in colorectal ...
and invasion. (A) TMPO-AS1 expression in cervical cancer cell lines (HeLa, SiHa, CaSki, C-33A) and HPV–immortalized cervical epithelial cell line (H8) was examined by qRT-PCR. (B) The overexpression efficiency of TMPO-AS1 in C-33A cells was confirmed by qRT-PCR. (C–E) Cell viabili...
[摘要]目的:探究长链非编码RNA(lncRNA)TMPO-ASl通过调节miR-204-3p的表达对肺癌细胞增殖、凋亡和侵袭的影响。方法:实时荧光定量PCR(qPCR)检测人肺癌细胞系A549、H1975、H1299和H1650和人正常支气管上皮细胞系HBE 中TMPO-AS1的表达水平。采用脂质体转染技术沉默A549细胞中TMPO-AS1,qPCR检测TMPO-AS1和miR-204-3p的...
Competing Endogenous TMPO-AS1-let-7c-5p-LDHA RNA Network Predicts the Prognosis of Lung Adenocarcinoma Patients doi:10.31557/APJCP.2024.25.10.3673Asian Pacific Journal of Cancer PreventionNema, RajeevVats, PrernaSingh, JaiSrivastava, Sandeep K.Kumar, Ashok...
沉默TMPO-AS1或miR-143-3p过表达后可降低细胞增殖,迁移,侵袭能力,促进细胞凋亡,PCNA,MMP-2表达下调,而酶切caspase-3表达上调;双荧光素酶报告实验证实TMPO-AS1可靶向结合miR-143-3p,并可调控miR-143-3p的表达及活性;干扰miR-143-3p表达可逆转沉默TMPO-AS1对肺癌细胞生物学行为的影响.结论沉默TMPO-AS1可通过上调...
增殖目的:探讨LncRNA TMPO-AS1对成骨细胞分化,增殖的影响及其对Nrf2/Keapl信号通路的调控作用.方法:采用地塞米松(Dex)处理人成骨肉瘤细胞MG63建立骨质疏松症细胞模型(Dex组),分别将pcDNA-NC,pcDNA-TMPO-AS1,si-NC,siTMPO-AS1转染至MG63细胞,分别将pcDNA-NC,pcDNA-TMPO-AS1转染至MG63细胞后加入Dex处理24 h,同时...
MiR-1270 inhibitors reversed the TMPO-AS1 knockdown's effect on suppressing the tumor cell proliferation, invasion, and glycolysis, while the knockdown of PKM2 further inverted the function of miR-1270 inhibitors on the TMPO-AS1 knockdown. Conclusions: This study illustrated that ...
LncRNA TMPO‐AS1ovarian cancertranscription factorOvarian cancer remains the sixth most frequently occurring cancer in women worldwide. Long noncoding RNAs (lncRNAs) are capable of regulating gene expression, and thus, participating in a wide range of biological functions and disease processes including...
However, TMPO-AS1's function in PCa bone metastasis (BM) and its underlying molecular mechanisms are unclear. Herein, we found that the long transcript of TMPO-AS1 (TMPO-AS1(L)) was upregulated in PCa tissues with bone metastasis, and overexpression of TMPO-AS1(L) correlated with advanced ...
Interestingly, the expression level of TMPO-AS1 was significantly correlated with clinicopathological features of the patients such as lymph node and distant metastasis. Conclusion: The overexpression of TMPO-AS1 gene in CRC suggests that this lncRNA and its underlying signaling pathways can be ...