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The predicted MLLT3 protein demonstrated a significant homology to that of the MLLT1 gene at 19p13 involved in t(11;19) leukemia. The highest homology, up to 74.1%, was found in 86 amino acids of the C-terminus, suggesting that this region is of particular importance for leukemogenesis in...
New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia.: The MLLT10 gene, located at 10p13, is a known partner of MLL and PICALM in specific
Mixed phenotype acute leukemia with t(11;19)(q23;p13.3)/ MLL-MLLT1(ENL), B/T-lymphoid type: A first case report 来自 EBSCO 喜欢 0 阅读量: 52 作者:M Naghashpour,J Lancet,L Moscinski,Z Ling 摘要: The majority of cases of acute leukemia belong to a specific lineage origin, either...
PICALM (clathrin-assembly protein-like lymphoid myeloid leukemia gene)-MLLT10 (formerly CALM-AF10) results from a recurring t(10;11)(p13;q14-21) chromosomal translocation and is the most frequent fusion transcript detected in patients with T-ALL, at an overall rate of 10%, including both ad...
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MLLT2, CT (T1196) (AFF1, AF4, FEL, MLLT2, PBM1, AF4/FMR2 family member 1, ALL1-fused gene from chromosome 4 protein, Protein FEL, Proto-oncogene AF4)供应商 MyBioSource产品货号 MBS643372产品报价 ￥询价/0.2mL ￥询价/5x0.2mL ￥询价/其它规格产品说明书 点击查看购买...
RNAseq结果示PICALM-MLLT10融合基因阳性,SMC3基因上检测到移码突变:c.2250_2251del(p.Lys751AsnfsTer5);JAK1基因上检测到错义突变:c.2108G>T(p.Ser703Ile)。骨髓TCR基因重排:检测到TCRβ、TCRγ和TCRδ基因发生重排。骨髓染色体核型:47,XY,+X[2]/46,XY[28]。骨髓活检:苏木素-伊红(HE)染色及过碘酸-...
Ben 等[14]研究发现,PICALM-MLLT10 融合基因阳性的 T-ALL 和急性早期前体 T 淋巴细胞白血病(early T-cell precursor acute lymphoblastic leukemia,ETP-ALL)患者在无事件生存期和总生存期上较 PICALM-MLLT10 融合基因阴性者更短,提示 PICALM-MLLT10 融合的患者预后差。此外,MLLT10 能与CALM、混合谱系白血病(mixed...
MLLT10 Knockout HEK293T Trizol Lysate (MLLT10基因敲除HEK293T细胞Trizol裂解液)是通过同时表达Cas9、目的基因sgRNA和puromycin抗性基因,并实现了目的基因CRISPR敲除的多克隆HEK293T细胞的Trizol裂解液。该细胞中目的基因的敲除已经通过T7EI法的验证。本产品可用于该目的基因敲除后其信号通路相关RNA表达的研究。