Often the CMT column of Nonmem data sets can simply be tagged as ADM column in Monolix. Using the library model files as a template, the user can then create a new model file adapting the depot statements in the PK: block to its need. In the case of iv and sub-cutaneous ...
When the Monolix project is exported to Mlxplore using the last estimated parameters, one indeed clearly see that the influence of kdeg and KD on the concentration-time curve is the same. It will therefore not be possible to identify both. In this case, options are: (i) fix the value ...
Monolix Code for Double TMDD Model References Paintaud, G.; Passot, C.; Ternant, D.; Bertolotto, A.; Bejan-Angoulvant, T.; Pascual-Salcedo, D.; Mulleman, D. Rationale for Therapeutic Drug Monitoring of Biopharmaceuticals in Inflammatory Diseases. Ther. Drug Monit. 2017, 39, 339–343. ...