Here, we present the real-world prevalence of TMB-High in a large cohort of gynecologic tumors and examine its correlation to other ICPI biomarkers. Methods: We retrospectively reviewed 17,304 gynecologic tumors tested with comprehensive genomic profiling (CGP). TMB was determined on 0.79 Mb of ...
“KEYNOTE-158 has confirmed clinical activity of pembrolizumab in tumors harboring a TMB ≥10 (TMB-High) across a variety of previously treated solid tumors including anal, biliary, cervical, endometrial, mesothelioma, neuroendocrine, salivary, small cell lung, thyroid, and vulvar cancers. A respons...
Expression of programmed cell death 1 (PD-1) ligand 1 (PD-L1) on tumor cells represents the most widely used clinical bio-marker for predicting response to immune checkpoint inhibition in non-small cell lung cancer (NSCLC). However, even among advanced NSCLCs with high PD-L1 expression on ...
上海玉博生物科技有限公司 主要致力于“TMB, High Kinetics AG总代理 TMB, High Kinetics AG Scientific.国内代理 ”的生产销售。多年的“TMB, High Kinetics AG总代理 TMB, High Kinetics AG Scientific.国内代理 ”生产与销售的经验,与各行业新老用户建立了稳定的合作关
产品名称:TMB, High Kinetics 产品型号: 产品展商:其它品牌 产品文档:无相关文档 简单介绍 CAS:54827-17-7Formula:C16H20N2MW:240.35Appearance:LiquidPurity:N/A TMB, High Kinetics的详细介绍 3,3',5,5'-Tetramethylbenzidine (TMB) has been shown to be a safe, sensitive substrate for the assay of ho...
In our exclusive interview, Vivek Subbiah, MD, discusses the FDA approval of pembrolizumab in tumor mutational burden–high solid tumors, shares the “transformative importance” of the regulatory decision, and speaks to the controversy surrounding the a
环绕着勃朗峰有一条传统的徒步旅行路线叫TMB(tour du mont blanc)徒步者会根据自身情况用6-7天来这条世界级徒步线路,UTMB的赛道就是脱胎于TMB环勃朗峰步道,UTMB(The Ultra-Traildu Mont-Blanc)就是在环勃朗峰的路线上举行的越野赛。 UTMB—在天际与高海拔的群山间肆意追逐,精彩绝伦的赛道赛道为越野跑的根基,...
这确实是TMB当前面临的一个问题,对于tTMB-H患者生存获益不显著这一点,主要的原因是KN-158的泛瘤种研究中纳入了大量常表现为tTMB-H状态,但预后差且治疗耐药性高的癌症(宫颈癌和小细胞肺癌,免疫原性差)患者,这类患者的进展时间快和早期死亡将会影响tTMB-H患者的中位生存结果。
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Immune checkpoint inhibitors have been approved in the USA for tumours exhibiting mismatch repair deficiency (dMMR), microsatellite instability (MSI), or high tumour mutational burden (TMB), with regulatory and reimbursement applications in multiple othe